Palladium-Catalyzed Phthalazinone Synthesis Using Paraformaldehyde as Carbon Source was written by Wang, Huamin;Cai, Jinhui;Huang, Huawen;Deng, Guo-Jun. And the article was included in Organic Letters in 2014.COA of Formula: C8H6BrFO2 This article mentions the following:
A palladium-catalyzed one-pot synthesis of phthalazinones I [ Ar = ph, 4-Me-ph, 4-Et-ph, 4-OMe-ph, etc.] from 2-halomethyl benzoates, paraformaldehyde, and aryl hydrazines is described. Various substituted phthalazinones were selectively obtained in good yields using paraformaldehyde as the cheap carbon source (CH). In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9COA of Formula: C8H6BrFO2).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.COA of Formula: C8H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary