Formation of substituted 1-naphthols and related products via dimerization of alkyl 3-(o-halo(het)aryl)-oxopropanoates based on a CuI-catalyzed domino C-arylation/condensation/aromatization process was written by Weischedel, Heike;Sudheendran, Kavitha;Mikhael, Alevtina;Conrad, Juergen;Frey, Wolfgang;Beifuss, Uwe. And the article was included in Tetrahedron in 2016.Formula: C8H6BrFO2 This article mentions the following:
Substrates bearing both a β-ketoester moiety and a (het)aryl halide structure element were dimerized to 1-naphthols and related products in the presence of catalytic amounts of CuI in isopropanol. The reaction starts with an intermol. C-arylation, which is followed by an intramol. condensation. The final aromatization delivers the highly substituted products with yields up to 81%. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Formula: C8H6BrFO2).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Formula: C8H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary