NickelII-catalyzed asymmetric photoenolization/Mannich reaction of (2-alkylphenyl) ketones was written by Yang, Liangkun;Li, Wang-Yuren;Hou, Liuzhen;Zhan, Tangyu;Cao, Weidi;Liu, Xiaohua;Feng, Xiaoming. And the article was included in Chemical Science in 2022.HPLC of Formula: 85118-24-7 This article mentions the following:
A diastereo- and enantioselective photoenolization/Mannich (PEM) reaction of ortho-alkyl aromatic ketones with benzosulfonimides were established by utilizing a chiral N,N’-dioxide/Ni(OTf)2 complex as the Lewis acid catalyst. It afforded a series of benzosulfonamides and the corresponding ring-closure products and a reversal of diastereoselectivity were observed through epimerization of the benzosulfonamide products under continuous irradiation On the basis of the control experiments, the role of the additive LiNTf2 in achieving high stereoselectivity were elucidated. This PEM reaction were proposed to undergo a direct nucleophilic addition mechanism rather than a hetero-Diels-Alder/ring-opening sequence. A possible transition state model with a photoenolization process were proposed to explain the origin of the high level of stereoinduction. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7HPLC of Formula: 85118-24-7).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 85118-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary