7′-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors was written by Zhang, Lin;Fan, Junhua;Vu, Khang;Hong, Kevin;Le Brazidec, Jean-Yves;Shi, Jiandong;Biamonte, Marco;Busch, David J.;Lough, Rachel E.;Grecko, Roy;Ran, Yingqing;Sensintaffar, John L.;Kamal, Adeela;Lundgren, Karen;Burrows, Francis J.;Mansfield, Robert;Timony, Gregg A.;Ulm, Edgar H.;Kasibhatla, Srinivas R.;Boehm, Marcus F.. And the article was included in Journal of Medicinal Chemistry in 2006.SDS of cas: 615-55-4 This article mentions the following:
We report on the discovery of benzo- and pyridino- thiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally sensitive to substitutions on the aromatic ring with a 7′-substituent essential for activity. Some of these compounds exhibit low nanomolar inhibition activity in a Her-2 degradation assay (28-150 nM), good aqueous solubility, and oral bioavailability profiles in mice. In vivo efficacy experiments demonstrate that compounds of this class inhibit tumor growth in an N87 human colon cancer xenograft model via oral administration as shown with compound 37 (8-(7-chlorobenzothiazol-2-ylsulfanyl)-9-(2-cyclopropylamino-ethyl)-9H- purin-6-ylamine)(I). In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4SDS of cas: 615-55-4).
3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.SDS of cas: 615-55-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary