Enantioselective Palladium-Catalyzed Intramolecular α-Arylative Desymmetrization of 1,3-Diketones was written by Zhu, Chendan;Wang, Dingyi;Zhao, Yue;Sun, Wei-Yin;Shi, Zhuangzhi. And the article was included in Journal of the American Chemical Society in 2017.Quality Control of 2-Bromo-4-fluorobenzylbromide This article mentions the following:
In the presence of Pd(OAc)2 and a nonracemic diphenylphosphinoferrocenyloxazoline (FOXAP) (or its enantiomer), 2-bromoarylalkyl 1,3-cycloalkanediones such as I underwent enantioselective intramol. arylation and desymmetrization to yield nonracemic bridged benzo-fused bicycloalkanediones such as II in 35-99% yields and in 73-95% ee; a bromobenzyl phenylcyclohexanedione underwent cyclization to yield a bridged dione as a single diastereomer in 94% ee. Using this method, the sesquiterpene (-)-parvifoline was prepared in fourteen steps and 92% ee. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Quality Control of 2-Bromo-4-fluorobenzylbromide).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Quality Control of 2-Bromo-4-fluorobenzylbromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary