Directed biosynthesis of 5”-fluoropactamycin in Streptomyces pactum was written by Adams, Erik S.;Rinehart, Kenneth L.. And the article was included in Journal of Antibiotics in 1994.Product Details of 827-24-7 This article mentions the following:
A new pactamycin analog, 5”-fluoropactamycin (I), was prepared by directed biosynthesis. Supplementation of the fermentation medium of Streptomyces pactum var. pactum with 3-amino-5-fluorobenzoic acid, an analog of 3-aminobenzoic acid, an advanced precursor in pactamycin biosynthesis, resulted in co-production of pactamycin and the new pactamycin analog. A similar feeding experiment with 3-amino-5-methylbenzoic acid did not result in formation of the corresponding methylated pactamycin analog, but only in inhibition of pactamycin production Comparison of antimicrobial and cytotoxic activities of pactamycin and I showed no significant differences. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Product Details of 827-24-7).
2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 827-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary