Balle, Thomas et al. published their research in Journal of Medicinal Chemistry in 2003 | CAS: 13273-53-5

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C3H4BrN3

Synthesis and Structure-Affinity Relationship Investigations of 5-Heteroaryl-Substituted Analogues of the Antipsychotic Sertindole. A New Class of Highly Selective α1 Adrenoceptor Antagonists was written by Balle, Thomas;Perregaard, Jens;Ramirez, Martha Teresa;Larsen, Anna Kirstine;Soby, Karina Krojer;Liljefors, Tommy;Andersen, Kim. And the article was included in Journal of Medicinal Chemistry in 2003.Formula: C3H4BrN3 This article mentions the following:

A new class of 5-heteroaryl-substituted 1-(4-fluorophenyl)-3-(4-piperidinyl)-1H-indoles, e.g., I (X = NH, O), as highly selective and potentially CNS-active α1-adrenoceptor antagonists is described. The compounds are derived from the antipsychotic sertindole. The structure-affinity relationships of the 5-heteroaryl substituents, and the substituents on the piperidine nitrogen atom were optimized with respect to affinity for α1 adrenoceptors and selectivity in respect to dopamine (D1-4) and serotonin (5-HT1A-1B and 5-HT2A,2C) receptors. The most selective compound obtained, 3-{4-[1-(4-fluorophenyl)-5-(1-methyl-1,2,4-triazol-3-yl)-1H-indol-3-yl]-1-piperidinyl}propionitrile (II), has affinities of 0.99, 3.2, and 9.0 nM for the α1a, α1b, and α1d adrenoceptor subtypes, resp., and a selectivity for adrenergic α1a receptors in respect to dopamine D2, D3, and D4 and serotonin 5-HT2A and 5-HT2C higher than 900, comparable to the selectivity of prazosin. Compound II is more than 150-fold selective in respect to serotonin 5-HT1A and 5-HT1B receptors. A new basic pharmacophore for α1-adrenoceptor antagonists based on a previously reported pharmacophore model for dopamine D2 antagonist is suggested. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Formula: C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary