New antibacterial cadiolide analogues active against antibiotic-resistant strains was written by Bekri, Sarra;Desriac, Florie;Barreau, Magalie;Clamens, Thomas;Gallavardin, Thibault;Nahenec-Martel, Patricia Le;Vieillard, Julien;Datoussaid, Yazid;Choukchou-Braham, Noureddine;Lesouhaitier, Olivier;Franck, Xavier;Leleu, Stephane. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Related Products of 108940-96-1 This article mentions the following:
The synthesis of new cadiolide analogs was carried out using a one-pot multicomponent synthesis. The antibacterial activity of these mols. was evaluated on standard and antibiotic-resistant bacterial strains chosen for their involvement in human health or in food-born poisoning. Four mols., I, II (R = Me, H), and III have shown good activities with MICs of 2μg/mL-1. The introduction of an indole group or the conversion of the lactone into lactam have highlighted two new families of mols. with promising antibacterial activity. In addition, most of these active mols. are devoid of cytotoxic activity against keratinocyte cells. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Related Products of 108940-96-1).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 108940-96-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary