Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans was written by Boegesoe, Klaus P.. And the article was included in Journal of Medicinal Chemistry in 1983.Application In Synthesis of 2-Bromo-4-(trifluoromethyl)benzaldehyde This article mentions the following:
The title compounds I (R = Me, Et, CH2CH2OH, CH2CONH2, CH2CH(OH)Me, etc.; R1 = H, Cl, F, Me, CF3, MeO, etc.; R2 = H, Cl, F, or Me; n = 1 or 2) as isomeric HCl salts prepared by 1,4-addition of substituted PhMgBr to Et 2-cyano-3-phenyl-2-propenoates, conversion to 3,3-diphenylpropanoic acids, cyclization to 3-phenylindan-1-ones, reduction with NaBH4 to 3-phenylindan-1-ols, chlorination with SOCl2 to 1-chloro-3-phenylindans and reaction with the appropriate piperazine, were tested for neuroleptic and thymoleptic activity. Neuroleptic activity as assessed by the ability of I to antagonize methylphenidate-induced stereotypies in mice, was found only in trans racemates and was associated with 1 of the enantiomers only. Thymoleptic activity was optimized, especially with respect to dopamine [51-61-6]-uptake inhibition; no geometrical stereoselectivity was found with regard to dopamine-uptake inhibition, but a high enantioselectivity could be demonstrated for both cis and trans racemates. Lu 18-012 (tefludazine)[(±)-trans-4-[3-(4-fluorophenyl)-6-(trifluoromethyl)indan-1-yl]-1-piperazineethanol] (I; R = CH2CH2OH, R1 = 6-CF3, R1 = 4′-F) [85118-23-6] a potent neuroleptic but a weak amine-uptake inhibitor was selected for clin. trials as an antipsychotic. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Application In Synthesis of 2-Bromo-4-(trifluoromethyl)benzaldehyde).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application In Synthesis of 2-Bromo-4-(trifluoromethyl)benzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary