Water enables an asymmetric cross reaction of α-keto acids with α-keto esters for the synthesis of quaternary isotetronic acids was written by Chen, Ping;Wang, Kai;Zhang, Boyu;Guo, Wengang;Liu, Yan;Li, Can. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Name: 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:
A water promoted asym. aldol/lactonization/enolization cascade reaction of α-keto acids R1CH2C(O)C(O)OH (R1 = H, Me) and α-keto esters R2C(O)C(O)OC(CH3)3 [R2 = 4-FC6H4(CH2)2, CH2=CH(CH2)2, C6H5CH2O(CH2)3, etc.] was developed, affording the first general protocol for the construction of chiral quaternary isotetronic acids I with excellent enantioselectivity. Theor. results indicate that intramol. ionized enamine intermediates stabilized by water generate zwitterionic transition states in a lower activation energy and higher face selectivity, resulting in high activity and chemo- and enantioselectivity. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Name: 1-(2-Bromoethyl)-4-methoxybenzene).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 1-(2-Bromoethyl)-4-methoxybenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary