Preliminary structure-activity relationship (SAR) of a novel series of pyrazole SKF-96365 analogues as potential store-operated calcium entry (SOCE) inhibitors was written by Dago, Camille D.;Le Maux, Paul;Roisnel, Thierry;Brigaudeau, Christophe;Bekro, Yves-Alain;Mignen, Olivier;Bazureau, Jean-Pierre. And the article was included in International Journal of Molecular Sciences in 2018.Category: bromides-buliding-blocks This article mentions the following:
From a series of [β-(phenylalkoxy)-(phenethyl)]-1H-pyrazolium hydrochloride as new analogs of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE)(IC50 25 μM) on the PLP-B lymphocyte cell line. A successful resolution of (±) 1-phenyl-2-(1H-pyrazol-1-yl)ethan-1-ol was developed by using the method of “half-concentration” in the presence of (+)-(1S)- or (-)-(1R)-CSA. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).
1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary