Duffey, Matthew O. et al. published their research in Journal of Medicinal Chemistry in 2012 | CAS: 95668-20-5

3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-Nitro-4-(trifluoromethoxy)bromobenzene

Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905) was written by Duffey, Matthew O.;Vos, Tricia J.;Adams, Ruth;Alley, Jennifer;Anthony, Justin;Barrett, Cynthia;Bharathan, Indu;Bowman, Douglas;Bump, Nancy J.;Chau, Ryan;Cullis, Courtney;Driscoll, Denise L.;Elder, Amy;Forsyth, Nancy;Frazer, Jonathan;Guo, Jianping;Guo, Luyi;Hyer, Marc L.;Janowick, David;Kulkarni, Bheemashankar;Lai, Su-Jen;Lasky, Kerri;Li, Gang;Li, Jing;Liao, Debra;Little, Jeremy;Peng, Bo;Qian, Mark G.;Reynolds, Dominic J.;Rezaei, Mansoureh;Scott, Margaret Porter;Sells, Todd B.;Shinde, Vaishali;Shi, Qiuju Judy;Sintchak, Michael D.;Soucy, Francois;Sprott, Kevin T.;Stroud, Stephen G.;Nestor, Michelle;Visiers, Irache;Weatherhead, Gabriel;Ye, Yingchun;D’Amore, Natalie. And the article was included in Journal of Medicinal Chemistry in 2012.Quality Control of 3-Nitro-4-(trifluoromethoxy)bromobenzene This article mentions the following:

This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chem. series produced an orally bioavailable inhibitor of PLK1 I (MLN0905). In vivo pharmacokinetic-pharmacodynamic experiments demonstrated prolonged mitotic arrest after oral administration of I to tumor bearing nude mice. A subsequent efficacy study in nude mice achieved tumor growth inhibition or regression in a human colon tumor (HT29) xenograft model. In the experiment, the researchers used many compounds, for example, 3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5Quality Control of 3-Nitro-4-(trifluoromethoxy)bromobenzene).

3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-Nitro-4-(trifluoromethoxy)bromobenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary