Cyclometalated (NNC)Ru(II) complex catalyzed β-methylation of alcohols using methanol was written by Ganguli, Kasturi;Belkova, Natalia V.;Kundu, Sabuj. And the article was included in Dalton Transactions in 2022.Computed Properties of C12H7BrN2 This article mentions the following:
Indolyl fragment containing phenanthroline based new ligands and their corresponding Ru(II) complexes I (R = H, OMe) were synthesized and fully characterized by various spectroscopic techniques. The catalytic activity of these newly synthesized cyclometalated (NNC)Ru(II) complexes I was explored towards the β-methylation of alcs. e.g., 1-phenylpropan-1-ol using methanol. Notably, these complexes I displayed superior reactivity compared to various (NNN)Ru(II) complexes. Utilizing this strategy, a wide range of primary, secondary, and aliphatic straight chain alcs. were selectively methylated. This protocol was further employed for the methylation of a few natural products and the gram scale synthesis of β-methylated alcs. A series of control experiments and kinetic studies was performed to understand the plausible reaction mechanism. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Computed Properties of C12H7BrN2).
2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Computed Properties of C12H7BrN2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary