Metastable doubly threaded [3]rotaxanes with a large macrocycle was written by Hertzog, Jerald E.;Maddi, Vincent J.;Hart, Laura F.;Rawe, Benjamin W.;Rauscher, Phillip M.;Herbert, Katie M.;Bruckner, Eric P.;de Pablo, Juan J.;Rowan, Stuart J.. And the article was included in Chemical Science in 2022.Related Products of 162258-89-1 This article mentions the following:
Ring size is a critically important parameter in many interlocked mols. as it directly impacts many of the unique mol. motions that they exhibit. Reported herein are studies using one of the largest macrocycles reported to date to synthesize doubly threaded [3]rotaxanes. A large ditopic 46 atom macrocycle containing two 2,6-bis(N-alkyl-benzimidazolyl)pyridine ligands was used to synthesize several metastable doubly threaded [3]rotaxanes in high yield (65-75% isolated) via metal templating. Macrocycle and linear thread components were synthesized and self-assembled upon addition of iron(II) ions to form the doubly threaded pseudo[3]rotaxanes that could be subsequently stoppered using azide-alkyne cycloaddition chem. Following demetallation with base, these doubly threaded [3]rotaxanes were fully characterized utilizing a variety of NMR spectroscopy, mass spectrometry, size-exclusion chromatog., and all-atom simulation techniques. Critical to the success of accessing a metastable [3]rotaxane with such a large macrocycle was the nature of the stopper group employed. By varying the size of the stopper group it was possible to access metastable [3]rotaxanes with stabilities in deuterated chloroform ranging from a half-life of <1 min to ca. 6 mo at room temperature potentially opening the door to interlocked materials with controllable degradation rates. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Related Products of 162258-89-1).
4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 162258-89-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary