Palladium-catalyzed intramolecular C(sp3)-H functionalization: catalyst development and synthetic applications was written by Hitce, Julien;Retailleau, Pascal;Baudoin, Olivier. And the article was included in Chemistry – A European Journal in 2007.Safety of Ethyl (2-bromophenyl)acetate This article mentions the following:
A novel catalytic system, based on a mixture of palladium acetate and tris(5-fluoro-2-methylphenyl)phosphine (F-TOTP), has been designed for the intramol. C-H functionalization of alkane segments. Among other analogs of tris(2-methylphenyl)phosphine (P(o-tol)3), F-TOTP was shown to have the optimal metal-bonding properties for this reaction. This catalytic system operated under milder reaction conditions that allowed the regioselective production of various olefins adjacent to a quaternary benzylic carbon atom, as well as novel bi- and tricyclic mols. E.g., palladium acetate/(F-TOTP) catalyzed the reaction of aryl alkane I to give 77% olefin II. A general mechanism was proposed, with the preferential formation of a six-membered palladium(II) palladacycle after oxidative addition and cyclopalladation. The regioselective C-H functionalization of alkyl groups into olefins was illustrated in the synthesis of the antihypertensive drug verapamil and an analog. A particularly mild ruthenium-catalyzed direct hydroamidation of the intermediate olefin in this synthesis is also reported. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Safety of Ethyl (2-bromophenyl)acetate).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of Ethyl (2-bromophenyl)acetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary