Nickel-Catalyzed Asymmetric Reductive Arylalkylation of Unactivated Alkenes was written by Jin, Youxiang;Wang, Chuan. And the article was included in Angewandte Chemie, International Edition in 2019.Reference of 4457-67-4 This article mentions the following:
Reported is an asym. reductive dicarbofunctionalization of unactivated alkenes [e.g., 1-bromo-2-(3-methylbut-3-en-1-yl)benzene + 4-bromobutyl acetate â?I (69%, 94% ee)]. Under the catalysis of a Ni/BOX system, various aryl bromides, incorporating a pendant olefinic unit, were successfully reacted with an array of primary alkyl bromides in the presence of Zn as a reductant, furnishing a series of benzene-fused cyclic compounds bearing a quaternary stereocenter in high enantioselectivities. Notably, this reaction avoids the use of pregenerated organometallics and demonstrates high tolerance of sensitive functionalities. The preliminary mechanistic investigations reveal that this Ni-catalyzed reaction proceeds as a cascade consisting of migratory insertion and cross-coupling with a nickel(I)-mediated intramol. 5-exo cyclization as the enantiodetermining step. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Reference of 4457-67-4).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Reference of 4457-67-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary