2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbonbromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 83902-02-7
Tachykinin NK-1 receptor probed with constrained analogs of substance P was written by Sagan, Sandrine;Josien, Hubert;Karoyan, Philippe;Brunissen, Alie;Chassaing, Gerard;Lavielle, Solange. And the article was included in Bioorganic & Medicinal Chemistry in 1996.Reference of 83902-02-7 This article mentions the following:
The action of rotameric probes introduced either in position 7 or 8 in the sequence of substance P (SP) was investigated. i.e., L-tetrahydroisoquinoleic acid (Tic), L-fluorenylglycine (Flg), L-diphenylalanine (Dip), the diastereoisomers of L-1-indanylglycine (Ing) and L-benz[f]indanylglycine (Bfi), the Z- and E-isomers of dehydrophenylalanine and dehydronaphthylalanine (ΔZPhe, ΔEPhe, ΔZNal, ΔENal) and L-o,o’-dimethylphenylalanine (Dmp). The aim this study was the topog. characterization of the binding subsites of human NK-1 receptor expressed in CHO cells, especially the S7 and S8 subsites, corresponding to residues Phe7 and Phe8 of substance P. According to the binding potencies of these substituted-SP analogs, the S7 binding subsite is smaller than the S8 subsite: the S7 subsite accepts only one aromatic nucleus, while the S8 can accommodate three coplanar nuclei altogether. These findings are compatible with the idea that the S8 binding subsite may reside in the extracellular loops of the hNK-1 receptor. NK-1 agonists bind to human NK-1 receptor and activate the production of both inositol phosphates and cAMP. As already quoted for septide, [pGlu6, Pro9]SP(6-11), discrepancies are observed between affinity (Ki) and activity (EC50) values for IPs production While a weak correlation between Ki and EC50 values for IPs production could be found (r= 0.70), an excellent correlation could be demonstrated between their affinities (Ki) and their potencies (EC50) for cAMP production (r= 0.97). The high potency (EC50) observed for “septide-like” mols. on PI hydrolysis, compared to their affinity is not an artifact related to the high level of NK-1 receptors expressed on CHO cells since a good correlation was found between EC50 values obtained for PI hydrolysis and those measured for spasmogenic activity in guinea pig ileum bioassay (r= 0.94). In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Reference of 83902-02-7).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbonbromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 83902-02-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary