The synthesis of 1,2-ethanediylbis(triphenylphosphonium) ditribromide as a new brominating agent in the presence of solvents and under solvent-free conditions was written by Salmasi, Reihaneh;Gholizadeh, Mostafa;Salimi, Alireza;Garrison, Jered C.. And the article was included in Journal of the Iranian Chemical Society in 2016.Quality Control of 4-Bromo-2-chloro-6-nitrophenol This article mentions the following:
The compound 1,2-ethanediylbis(triphenylphosphonium) ditribromide was quant. prepared and used for the bromination of anilines, e.g., N,N-dimethylaniline yielding 4-bromo-N,N-dimethylaniline and phenols, e.g., 2-chloro-6-nitrophenol yielding 4-bromo-2-chloro-6-nitrophenol in the presence of a mixed solvent system (DCM/MeOH 2:1) and also under solvent-free conditions. This new ionic liquid has advantages over similar brominating agents in terms of short reaction time, simple workup, regioselectivity and high yields. Single crystal X-ray anal. of title salt revealed that the bistriphenylphosphonium cation is organized around an inversion center located at the center of the -CH2-CH2– bridge and the two triphenylphosphine segments are anti with respect to one another. All the tribromide anions adopt a linear geometry with different Br-Br-Br bond angles for each anion. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-chloro-6-nitrophenol (cas: 58349-01-2Quality Control of 4-Bromo-2-chloro-6-nitrophenol).
4-Bromo-2-chloro-6-nitrophenol (cas: 58349-01-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 4-Bromo-2-chloro-6-nitrophenol
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary