Thiolated amphiphilic β-cyclodextrin-decorated gold colloids: Synthesis, supramolecular nanoassemblies and controlled release of dopamine was written by Trapani, Mariachiara;Scala, Angela;Mineo, Placido G.;Pistone, Alessandro;Diaz-Moscoso, Alejandro;Fragoso, Alex;Monsu Scolaro, Luigi;Mazzaglia, Antonino. And the article was included in Journal of Molecular Liquids in 2021.Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:
We report a hybrid nanoassembly based on gold colloids decorated with a new thiolated amphiphilic cyclodextrin complexing dopamine (AuNPs@SC16SH/DA). The novel amphiphilic β-cyclodextrin SC16SH, bearing on average one thiol group at the end of an oligoethylene glycol chain per CyD unit, was obtained in a multi-step synthesis and fully characterized by NMR spectroscopy and MALDI anal. The AuNPs@SC16SH hybrid assembly was prepared by mixing AuNPs and SC16SH in aqueous solution and investigated by UV/Vis and TEM measurements. The AuNPs@SC16SH/DA supramol. assembly, bearing both thiol-stabilized gold nanoparticles and the neurotransmitter dopamine, has been conceived as stimuli-responsive delivery system able to control the release of dopamine upon proper stimuli. Two redox functionalities (i.e. the Au-S bond and the redox behavior of dopamine) have been exploited to detach SC16SH/DA complex from the AuNPs@SC16SH/DA progenitor platform, using dithiothreitol (DTT), and to detect the complex by cyclic voltammetry (CV). Following, dopamine was finally released from the SC16SH/DA assembly upon treatment with Brij S20 and the free dopamine was monitored by CV. Overall, our hybrid nanoassemblies turned out to be able to release dopamine, upon combined action of redox and digestion agents in medium emulating biol. environment. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary