Copper-Catalyzed Amide Radical-Directed Cyanation of Unactivated Csp3-H Bonds was written by Zhang, Hongwei;Zhou, Yulu;Tian, Peiyuan;Jiang, Cuiyu. And the article was included in Organic Letters in 2019.Name: 1-Bromo-4-methoxybutane This article mentions the following:
N-alkyl-N-fluorosulfonamides such as I (Ts = 4-MeC6H4SO2) underwent chemoselective and regioselective cyanation with TsCN in the presence of CuCN and bathocuproine (2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline) in 1,2-dichloroethane to yield δ-(sulfonylamino)nitriles such as II. The N-fluorosulfonamides were prepared in most cases in two steps from the corresponding amines and sulfonyl chlorides. Trapping experiments and ring opening of an N-cyclopropanebutylsulfonamide support the presence of radical intermediates; the reaction is proposed to occur by Cu(I)-mediated N-F bond cleavage to generate an amidyl radical, 1,5-hydrogen atom transfer, and cyanation of the resulting carbon radical with TsCN. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Name: 1-Bromo-4-methoxybutane).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: 1-Bromo-4-methoxybutane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary