Ni-Catalyzed Reductive 1,2-Cross-Dialkylation of Unactivated Alkenes with Two Alkyl Bromides was written by Zhang, Jian-Xin;Shu, Wei. And the article was included in Organic Letters in 2022.Reference of 4457-67-4 This article mentions the following:
Herein, a Ni-catalyzed reductive 1,2-dialkylation of unactivated aliphatic alkenes had been developed using two different alkyl bromides to gave (cyanoethyl)-alkyl-aryl-propanamides R1CH2CHR2CH2C(O)NHAr [R1 = cyanomethyl, H2CCO2Et, (2-oxotetrahydrofuran-3-yl); R2 = Et, n-Pr, 3-phenylpropyl, etc.; Ar = Ph, 4-MeC6H4, 3-MeOC6H4, etc.]. The reaction proceeded smoothly under mild conditions to install two Csp3-Csp3 bonds onto directed aliphatic alkenes, demonstrating excellent chemo- and regioselectivity with good functional group tolerance. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Reference of 4457-67-4).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 4457-67-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary