Month: January 2023

Copper-Catalyzed Enantioselective Conjugate Addition of Grignard Reagents to Methyl 4,4,4-Trifluorocrotonate: Synthesis of Enantioenriched Trifluoromethylated Compounds was written by Zhang, Li-Ying;Zhou, Jia-Hui;Xu, Yun-He;Loh, Teck-Peng. And the article was included in Chemistry – An Asian Journal in 2015.Application of 14425-64-0 This article mentions the following:

Copper-catalyzed enantioselective 1,4-conjugate addition of Me 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asym. tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products were obtained in reasonable yields and good enantioselectivities. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Effects of a chemically modified multiwall carbon nanotubes on electro-optical properties of PDLC films was written by Wu, Yong;Cao, Hui;Duan, Manyu;Li, Erli;Wang, Huihui;Yang, Zhou;Wang, Dong;He, Wanli. And the article was included in Liquid Crystals in 2018.Computed Properties of C13H14BrNO2 This article mentions the following:

Polymer dispersed liquid crystal (PDLC) films are fabricated by well-known polymerization-induced phase separation method. In this paper, the dispersion of multi-walled carbon nanotubes (MWCNT) in liquid crystals has been enhanced by chem. modification and we have investigated their effects on the morphol., electro-optical properties and conductivity of the PDLC films. Results indicated that the threshold voltage and the saturation voltage of PDLC films decreased with the increase of the doping concentration of MWCNT or chem. modified MWCNT, because carbon nanotubes can enhance the elec. field by reducing the resistivity of the medium and increasing the capacitance of the cells. It can be viewed obviously that the contrast ratio of the PDLC films doped with the chem. modified MWCNT is higher than that of the MWCNT. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Migratory Reductive Acylation between Alkyl Halides or Alkenes and Alkyl Carboxylic Acids by Nickel Catalysis was written by He, Jun;Song, Peihong;Xu, Xianfeng;Zhu, Shaolin;Wang, You. And the article was included in ACS Catalysis in 2019.Formula: C10H13BrO This article mentions the following:

A mild migratory reductive acyl cross-coupling has been achieved through NiH-catalyzed chainwalking and subsequent cross-coupling from two abundant starting materials, alkyl bromides, and carboxylic acids. This strategy allows the direct acylation of the benzylic sp³ C-H bond with high yield as a single regioisomer. As an alternative, the alkyl bromide could be replaced by the proposed olefin intermediate and com. available n-PrBr to achieve a remote hydroacylation process. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Formula: C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Forming Tertiary Organolithiums and Organocuprates from Nitrile Precursors and their Bimolecular Reactions with Carbon Electrophiles to Form Quaternary Carbon Stereocenters was written by Schnermann, Martin J.;Untiedt, Nicholas L.;Jimenez-Oses, Gonzalo;Houk, Kendall N.;Overman, Larry E.. And the article was included in Angewandte Chemie, International Edition in 2012.Product Details of 57293-19-3 This article mentions the following:

A general procedure for the synthesis of tertiary trialkyl-substituted organolithiums and organocuprates was reported. These intermediates was employed in the stereocontrolled construction of quaternary carbon stereocenters. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Product Details of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of α-naphthylthiourea was written by Maruta, Seizaburo. And the article was included in Eisei Shikensho Hokoku in 1950.Application of 57293-19-3 This article mentions the following:

For synthesis of α-naphthylthiourea the method of Hatt and Troyahn has been modified. To 15 g. naphthalene in 15 g. glacial AcOH, is added 9.17 g. 83% HNO₃ drop by drop at 40° with stirring, and the solution allowed to cool on standing to precipitate 18.2 g. α-nitronaphthalene. α-Nitronaphthalene (15 g.), 15.6 g. Fe dust, 4.5 g. H₂O, 2 g. NaCl, and 0.3 g. 30% HCl, kept at 80-90° 2.5 hrs. with stirring, the solution made alk. with NaOH, extracted with benzene, evaporated, the residue dissolved in EtOH, and acidified with HCl to precipitate 13.9 g. α-naphthylamine-HCl. This (15 g.) in 45 ml. water is treated with 5-7.5 g. NH₄CNS at 105° for 5 hrs. to yield 15.7-16.2 g. crystalline α-naphthylthiourea, m. 184° (from alc.). In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Application of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Transition-metal-free approaches to 2,3-diarylated indenones from 2-alkynylbenzaldehydes and phenols with tunable selectivity was written by Yao, Tuanli;Zhao, Shuaijing;Liu, Tao;Wu, Yuting;Ma, Yanhui;Li, Tao;Qin, Xiangyang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.COA of Formula: C9H6BrF3O2 This article mentions the following:

The first transition-metal-free regioselective synthesis of 2,3-diarylindenones via tandem annulation of 2-alkynylbenzaldehydes with phenols was described. Two different modes of reaction controlled by electronic effects and temperature furnished either “non-rearranged” or “rearranged” indenones in high selectivity. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8COA of Formula: C9H6BrF3O2).

Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C9H6BrF3O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth was written by Desai, Janish;Wang, Yang;Wang, Ke;Malwal, Satish R.;Oldfield, Eric. And the article was included in ChemMedChem in 2016.Name: 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

We synthesized potential inhibitors of farnesyl diphosphate synthase (FPPS), undecaprenyl diphosphate synthase (UPPS), or undecaprenyl diphosphate phosphatase (UPPP), and tested them in bacterial cell growth and enzyme inhibition assays. The most active compounds were found to be bisphosphonates with electron-withdrawing aryl-alkyl side chains which inhibited the growth of Gram-neg. bacteria (Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa) at âˆ?-4 μg mL^-1 levels. They were found to be potent inhibitors of FPPS; cell growth was partially “rescued” by the addition of farnesol or overexpression of FPPS, and there was synergistic activity with known isoprenoid biosynthesis pathway inhibitors. Lipophilic hydroxyalkyl phosphonic acids inhibited UPPS and UPPP at micromolar levels; they were active (âˆ?-6 μg mL^-1) against Gram-pos. but not Gram-neg. organisms, and again exhibited synergistic activity with cell wall biosynthesis inhibitors, but only indifferent effects with other inhibitors. The results are of interest because they describe novel inhibitors of FPPS, UPPS, and UPPP with cell growth inhibitory activities as low as âˆ?-2 μg mL^-1. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Name: 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Inhibition of Trypanosoma cruzi Hexokinase by Bisphosphonates was written by Hudock, Michael P.;Sanz-Rodriguez, C. E.;Song, Yongcheng;Chan, Julian M. W.;Zhang, Yonghui;Odeh, Sarah;Kosztowski, Thomas;Leon-Rossell, Annette;Concepcion, J. L.;Yardley, Vanessa;Croft, Simon L.;Urbina, Julio A.;Oldfield, Eric. And the article was included in Journal of Medicinal Chemistry in 2006.Recommanded Product: 3-Bromophenyl acetate This article mentions the following:

Hexokinase is the first enzyme involved in glycolysis in most organisms, including the etiol. agents of Chagas disease (Trypanosoma cruzi) and African sleeping sickness (Trypanosoma brucei). The T. cruzi enzyme is unusual since, unlike the human enzyme, it is inhibited by inorganic diphosphate (PPi). Here, we show that non-hydrolyzable analogs of PPi, bisphosphonates, are potent inhibitors of T. cruzi hexokinase. We determined the activity of 42 bisphosphonates against TcHK, and the IC₅₀ values were used to construct pharmacophore and comparative mol. similarity indexes anal. (CoMSIA) models for enzyme inhibition. Both models revealed the importance of electrostatic, hydrophobic, and steric interactions, and the IC₅₀ values for 17 active compounds were predicted with an average error of 2.4× by using the CoMSIA models. The compound most active against T. cruzi hexokinase was found to have a 2.2 μM IC₅₀ vs. the clin. relevant intracellular amastigote form of T. cruzi, but only a âˆ?-2 mM IC₅₀ vs. Dictyostelium discoideum and a human cell line, indicating selective activity vs. T. cruzi. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Recommanded Product: 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Selective Preparation of Xanthones from 2-Bromofluorobenzenes and Salicylaldehydes via Palladium-Catalyzed Acylation-SNAr Approach was written by Shen, Chaoren;Wu, Xiao-Feng. And the article was included in Synlett in 2016.SDS of cas: 452-62-0 This article mentions the following:

A regioselective pathway for the preparation of xanthones from 2-bromofluorobenzenes and salicylaldehydes was developed. The reaction proceeded through palladium-catalyzed acylation-S_NAr sequence. Good to moderate yields of the desired xanthones were prepared in one step. Based on the results of control experiments, a possible reaction mechanism is proposed. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0SDS of cas: 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.SDS of cas: 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Amide Radical-Directed Cyanation of Unactivated C_sp³-H Bonds was written by Zhang, Hongwei;Zhou, Yulu;Tian, Peiyuan;Jiang, Cuiyu. And the article was included in Organic Letters in 2019.Name: 1-Bromo-4-methoxybutane This article mentions the following:

N-alkyl-N-fluorosulfonamides such as I (Ts = 4-MeC₆H₄SO₂) underwent chemoselective and regioselective cyanation with TsCN in the presence of CuCN and bathocuproine (2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline) in 1,2-dichloroethane to yield δ-(sulfonylamino)nitriles such as II. The N-fluorosulfonamides were prepared in most cases in two steps from the corresponding amines and sulfonyl chlorides. Trapping experiments and ring opening of an N-cyclopropanebutylsulfonamide support the presence of radical intermediates; the reaction is proposed to occur by Cu(I)-mediated N-F bond cleavage to generate an amidyl radical, 1,5-hydrogen atom transfer, and cyanation of the resulting carbon radical with TsCN. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Name: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary