Month: January 2023

Quinonemethides and pseudophenol halides was written by Lindemann, Hans. And the article was included in Annalen der Chemie, Justus Liebigs in 1923.Product Details of 108940-96-1 This article mentions the following:

An investigation has been carried out with o- and p-hydroxybenzal halides and the compounds resulting by splitting of HX from them. 3,5,4-Br₂(HO)C₆H₂CHO, m. 185°. Triacetate, m. 125°. 4-MeO derivative, m. 82-6°, by warming the Na salt of the aldehyde with Me₂SO₄. The benzal bromide m. 60-4°. 3,5-Dibromo-4-hydroxybenzal bromide (I), m. 98-101.5°, results from the aldehyde and PBr₅ in C₆H₆. Hot AcOH or aqueous or alc. KOH transforms it into the aldehyde. The acetate, m. 80°, results by short warming with Ac₂O and a few drops of concentrated H₂SO₄. If I in a little Et₂O is shaken 2 min. with 2 volumes of 2 N AcONa, 3,5-dibromoquinone bromomethide, C₇H₃OBr₃, results, pale yellow, m. 120° if crystallized from CHCl₃, but from C₆H₆ or CS₂ a polymerized form is usually obtained, reddening at 120° and m. about 200°. H₂O transforms it to the aldehyde. HBr gives I, HCl the benzal bromide chloride, m. 70-4°. PhNH₂ gives the anil, orange, m. 150-2°, also obtained from the aldehyde or I with PhNH₂. NH₄OH or aqueous alkali at first gives a deep blue solution, gradually changing to a pale yellow which contains the alkali salt of the aldehyde. 2-Hydroxy-4,6-dimethylbenzaldehyde, m. 48°. Phenylhydrazone, m. 127°. 3,5-Dibromo-2,6-dimethyl-4-hydroxybenzaldehyde, m. 181°. Triacetate, m. 114°. Monoacetate, m. 149°. The benzal bromide m. 154°. Acetate, m. 152°. Anil, m. 212°. 3,5-Dibromo-2,6-dimethylquinone bromomethide, C₉H₇OBr₃, pale yellow, m. about 200°. Polymerization proceeds more rapidly in the hot. 3,5-Dibromo-2,6-dimethyl-4-hydroxybenzal chloride, m. 153°. Acetate, m. 128°. The quinone chloromethide is pale yellow and m. 132°, then 242°. 3,5-Dibromo-4-hydroxy-2,6-dimethylbenzal chloride bromide, m. 151°. Acetate, m. 138°. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Product Details of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Efficient Syntheses of Star-Branched, Multifunctional Mesogens was written by Song, Shuang;Rudick, Jonathan G.. And the article was included in Organic Letters in 2015.Application In Synthesis of N-(5-Bromopentyl)phthalimide This article mentions the following:

Star-branched mol. architectures lend themselves to convergent synthesis strategies for creating materials that combine three or more functional modalities, but these approaches require a core moiety with several reactive groups that are orthogonal to one another. The direct synthesis of three-arm, star-branched mesogens has been investigated via the Passerini three-component reaction to demonstrate how multicomponent reactions circumvent the need to identify and synthesize specialized branched core mols. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Application In Synthesis of N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Side chain methyl analogs of Δ⁸-THC was written by Huffman, John W.;Lainton, Julia A. H.;Banner, W. Kenneth;Duncan, Sammy G. Jr.;Jordan, Robert D.;Yu, Shu;Dai, Cong;Martin, Billy R.;Wiley, Jenny L.;Compton, David R.. And the article was included in Tetrahedron in 1997.Safety of Isopentyltriphenylphosphonium bromide This article mentions the following:

The synthesis of both side chain epimers of 1′- (I; R = CHMeBu) 2′- (I; R = CH₂CHMePr) and 3′-Me- [I; R = (CH₂)₂CHMeEt] and 4′-methyl-Δ⁸-tetrahydrocannabinol [I; R = (CH₂)₃CHMe₂] was carried out. The synthetic approach entailed the acid catalyzed condensation of the appropriate substituted resorcinol with menthadienol to provide the analog of Δ⁸-THC [I; R = (CH₂)₄Me]. Both isomers of 1′-Me- (I; R = CHMeBu) and 2′-Me-Δ⁸-THC (I; R = CH₂CHMePr) were more potent than Δ⁸-THC , both in vitro and in vivo. The 3′-Me isomers (I; R = CH₂CH₂CHMeEt) were approx. equal in potency to Δ⁸-THC, and 4′-methyl-Δ⁸-THC was less potent. There was relatively little difference in potency between the epimers of I (R = CHMeBu, CH₂CHMePr, CH₂CH₂CHMeE). In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Safety of Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of hexaaza [1.1](3,6)phenanthrenophane, a new heteromacrocyclic compound was written by Ogawa, Shojiro;Gotoh, Nobuyuki. And the article was included in Seisan Kenkyu in 1972.Quality Control of 2-Bromo-1,10-phenanthroline This article mentions the following:

Orange-yellow title compound (I), m. >500° and having low elec. resistance (�012Ωcm) which was decreased by �0% on irradiation, was prepared 2-Chloro-1,10-phenanthroline (II; R = Cl, R1 = H) was treated with Me2SO4 to give the methosulfate (III; R = Cl, X = MeSO4), which was treated with K3[Fe(CN)6]-NaOH to give 94% IV (R = Cl) (IVa). IV (R = H) was treated with PBr3-POBr3 to give 84% II (R = Br, R1 = H), which was converted into the methiodide (III, R = Br, X = I) and treated with K3[Fe(CN)6]NaOH to give 92.5% IV (R = Br), which on treating with PBr3-POBr3 gave II (R = R1 = Br). Similarly IVa and PBr3-POBr3 (or PCl3-POCl3) gave II (R = R1 = Cl) (IIa) (or II; R = Cl, R1 = Br) (IIb). NH3 was passed into a solution of IIa in AcNH2PhOH to give 89% II (R = R1 = NH2) (IIc). IIc, IIb, K2CO3 PhNO2 was heated at 180° to give 55% I. IIc, IIb, K2CO3,CuCl2 and PhNO2 was heated at 180% to give V (M = Cu). Similarly prepared were V (M = Co, Ni). In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Quality Control of 2-Bromo-1,10-phenanthroline).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of 2-Bromo-1,10-phenanthroline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Alkylboronic Esters from Palladium- and Nickel-Catalyzed Borylation of Primary and Secondary Alkyl Bromides was written by Yi, Jun;Liu, Jin-Hui;Liang, Jun;Dai, Jian-Jun;Yang, Chu-Ting;Fu, Yao;Liu, Lei. And the article was included in Advanced Synthesis & Catalysis in 2012.SDS of cas: 954-81-4 This article mentions the following:

Pd- and Ni-catalyzed cross-coupling reactions of unactivated alkyl bromides with diboron reagents were developed as practical methods for the synthesis of primary and secondary alkylboronic esters. These reactions extend the concept and utility of Pd- and Ni-catalyzed cross-coupling of aliphatic electrophiles. They also show different substrate selectivity and ligand dependence as compared to the recently reported Cu-catalyzed borylation reaction. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4SDS of cas: 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.SDS of cas: 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems was written by Diaz-Moscoso, Alejandro;Balbuena, Patricia;Gomez-Garcia, Marta;Ortiz Mellet, Carmen;Benito, Juan M.;Le Gourrierec, Loic;Di Giorgio, Christophe;Vierling, Pierre;Mazzaglia, Antonino;Micali, Norberto;Defaye, Jacques;Garcia Fernandez, Jose M.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2008.Formula: C42H63Br7O28 This article mentions the following:

Self-assembled cyclodextrin (CD)-DNA nanoparticles (CDplexes) exhibiting transfection efficiencies significantly higher than PEI-based polyplexes have been prepared from homogeneous seven-fold sym. polyaminothiourea amphiphiles constructed on a β-cyclodextrin scaffold. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Formula: C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Formula: C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors was written by Palve, Vinayak;Knezevic, Claire E.;Bejan, Daniel S.;Luo, Yunting;Li, Xueli;Novakova, Silvia;Welsh, Eric A.;Fang, Bin;Kinose, Fumi;Haura, Eric B.;Monteiro, Alvaro N.;Koomen, John M.;Cohen, Michael S.;Lawrence, Harshani R.;Rix, Uwe. And the article was included in Cell Chemical Biology in 2022.SDS of cas: 850462-65-6 This article mentions the following:

PARP inhibitors (PARPis) display single-agent anticancer activity in small cell lung cancer (SCLC) and other neuroendocrine tumors independent of BRCA1/2 mutations. Here, we determine the differential efficacy of multiple clin. PARPis in SCLC cells. Compared with the other PARPis rucaparib, olaparib, and niraparib, talazoparib displays the highest potency across SCLC, including SLFN11-neg. cells. Chem. proteomics identifies PARP16 as a unique talazoparib target in addition to PARP1. Silencing PARP16 significantly reduces cell survival, particularly in combination with PARP1 inhibition. Drug combination screening reveals talazoparib synergy with the WEE1/PLK1 inhibitor adavosertib. Global phosphoproteomics identifies disparate effects on cell-cycle and DNA damage signaling thereby illustrating underlying mechanisms of synergy, which is more pronounced for talazoparib than olaparib. Notably, silencing PARP16 further reduces cell survival in combination with olaparib and adavosertib. Together, these data suggest that PARP16 contributes to talazoparib′s overall mechanism of action and constitutes an actionable target in SCLC. In the experiment, the researchers used many compounds, for example, Methyl 2-(bromomethyl)-5-fluoro-3-nitrobenzoate (cas: 850462-65-6SDS of cas: 850462-65-6).

Methyl 2-(bromomethyl)-5-fluoro-3-nitrobenzoate (cas: 850462-65-6) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.SDS of cas: 850462-65-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents was written by Patch, Raymond J.;Searle, Lily L.;Kim, Alexander J.;De, Debyendu;Zhu, Xizhen;Askari, Hossein B.;O’Neill, John C.;Abad, Marta C.;Rentzeperis, Dionisios;Liu, Jianying;Kemmerer, Michael;Lin, Ling;Kasturi, Jyotsna;Geisler, John G.;Lenhard, James M.;Player, Mark R.;Gaul, Micheal D.. And the article was included in Journal of Medicinal Chemistry in 2011.Recommanded Product: Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally implicated in the regulation of energy homeostasis. Herein is described the development of diaryl ether based thiazolidenediones, which function as selective ligands against this receptor. Series optimization provided several potent analogs that inhibit the recruitment of a coactivator peptide fragment in in vitro biochem. assays (IC₅₀ < 150 nM) and cellular two-hybrid reporter assays against the ligand binding domain (IC₅₀ = 1-5 μM). A cocrystal structure of the ligand-binding domain of ERRα with lead compound 29 (I) revealed the presence of a covalent interaction between the protein and ligand, which has been shown to be reversible. In diet-induced murine models of obesity and in an overt diabetic rat model, oral administration of 29 normalized insulin and circulating triglyceride levels, improved insulin sensitivity, and was body weight neutral. This provides the first demonstration of functional activities of an ERRα ligand in metabolic animal models. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Recommanded Product: Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regio- and Stereoselective Synthesis of Ynenamides through Gold(I)-Catalyzed Hydroalkynylation of Ynamides was written by Siera, Hannah;Kreuzahler, Mathis;Wolper, Christoph;Haberhauer, Gebhard. And the article was included in European Journal of Organic Chemistry in 2022.COA of Formula: C4H4BrNO2 This article mentions the following:

Herein, regio- and stereoselective preparation of ynenamides I [R = Pr, cyclopropyl, Ph, etc.] via gold(I)-catalyzed hydroalkynylation of ynamides was exptl. shown. A wide range of products could be generated with yields up to 90% and, in contrast to many other gold-catalyzed alkyne dimerization reactions, alkyl groups were tolerated. Quantum chem. calculations and NMR labeling experiments revealed a mechanism via dual gold catalysis. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5COA of Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.COA of Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Structure-Affinity Relationship Investigations of 5-Heteroaryl-Substituted Analogues of the Antipsychotic Sertindole. A New Class of Highly Selective α₁ Adrenoceptor Antagonists was written by Balle, Thomas;Perregaard, Jens;Ramirez, Martha Teresa;Larsen, Anna Kirstine;Soby, Karina Krojer;Liljefors, Tommy;Andersen, Kim. And the article was included in Journal of Medicinal Chemistry in 2003.Formula: C3H4BrN3 This article mentions the following:

A new class of 5-heteroaryl-substituted 1-(4-fluorophenyl)-3-(4-piperidinyl)-1H-indoles, e.g., I (X = NH, O), as highly selective and potentially CNS-active α₁-adrenoceptor antagonists is described. The compounds are derived from the antipsychotic sertindole. The structure-affinity relationships of the 5-heteroaryl substituents, and the substituents on the piperidine nitrogen atom were optimized with respect to affinity for α₁ adrenoceptors and selectivity in respect to dopamine (D_1-4) and serotonin (5-HT_1A-1B and 5-HT_2A,2C) receptors. The most selective compound obtained, 3-{4-[1-(4-fluorophenyl)-5-(1-methyl-1,2,4-triazol-3-yl)-1H-indol-3-yl]-1-piperidinyl}propionitrile (II), has affinities of 0.99, 3.2, and 9.0 nM for the α_1a, α_1b, and α_1d adrenoceptor subtypes, resp., and a selectivity for adrenergic α_1a receptors in respect to dopamine D₂, D₃, and D₄ and serotonin 5-HT_2A and 5-HT_2C higher than 900, comparable to the selectivity of prazosin. Compound II is more than 150-fold selective in respect to serotonin 5-HT_1A and 5-HT_1B receptors. A new basic pharmacophore for α₁-adrenoceptor antagonists based on a previously reported pharmacophore model for dopamine D₂ antagonist is suggested. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Formula: C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary