Month: January 2023

Directed biosynthesis of 5”-fluoropactamycin in Streptomyces pactum was written by Adams, Erik S.;Rinehart, Kenneth L.. And the article was included in Journal of Antibiotics in 1994.Product Details of 827-24-7 This article mentions the following:

A new pactamycin analog, 5”-fluoropactamycin (I), was prepared by directed biosynthesis. Supplementation of the fermentation medium of Streptomyces pactum var. pactum with 3-amino-5-fluorobenzoic acid, an analog of 3-aminobenzoic acid, an advanced precursor in pactamycin biosynthesis, resulted in co-production of pactamycin and the new pactamycin analog. A similar feeding experiment with 3-amino-5-methylbenzoic acid did not result in formation of the corresponding methylated pactamycin analog, but only in inhibition of pactamycin production Comparison of antimicrobial and cytotoxic activities of pactamycin and I showed no significant differences. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Product Details of 827-24-7).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 827-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-catalyzed synthesis of 2,2,2-trifluoroethyl selenoethers and their insecticidal activities was written by Dong, Jingnan;Li, Zhengyu;Weng, Zhiqiang. And the article was included in Organic & Biomolecular Chemistry in 2018.Application of 14425-64-0 This article mentions the following:

A simple and efficient protocol for the synthesis of aryl/alkyl-2,2,2-trifluoroethyl selenoethers RSeCH₂CF₃ [R = 2-CNC₆H₄, 1-naphthyl, 2-quinolinyl, etc.] was developed via CuI/phen-catalyzed reductive 2,2,2-trifluoroethylselenolation of elemental selenium, 1,1,1-trifluoro-2-iodoethanes with aryl/alkyl halides. Different functional groups were tolerated and moderate to excellent yields of 2,2,2-trifluoroethyl selenoethers were obtained. Some of the synthesized compounds exhibited promising insecticidal activities. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chiral Cyclopentadienyl Ligands Enable a Rhodium(III)-Catalyzed Enantioselective Access to Hydroxychromanes and Phthalides was written by Ye, Baihua;Cramer, Nicolai. And the article was included in Synlett in 2015.Recommanded Product: Methyl 3-bromo-5-hydroxybenzoate This article mentions the following:

The demand for efficient chiral cyclopentadienyl ligands (Cp^x) has increased significantly in recent years, partly because Cp*Rh(III) species have been developed as powerful catalysts for directed C-H functionalization reactions. However, a lack of suitable Cp^x ligands has hampered the development of the corresponding enantioselective processes. We report expansions of the libraries of two generations of Cp^x ligands and their corresponding rhodium(I) complexes. The potential of the rhodium complexes as catalysts was evaluated in enantioselective C-H functionalizations involving cyclizations across tethered aldehydes. The mild reaction conditions permit the syntheses of hydroxychromanes and phthalides in good yields and high enantioselectivities. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Recommanded Product: Methyl 3-bromo-5-hydroxybenzoate).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: Methyl 3-bromo-5-hydroxybenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Novel intramolecular π-π-interaction in a BODIPY system by oxidation of a single selenium center: geometrical stamping and spectroscopic and spectrometric distinctions was written by Kim, Youngsam;Jun, Taehong;Mulay, Sandip V.;Manjare, Sudesh T.;Kwak, Jinseong;Lee, Yunho;Churchill, David G.. And the article was included in Dalton Transactions in 2017.Computed Properties of C5H3BrOS This article mentions the following:

A new BODIPY system displaying an intramol. π-π-interaction was synthesized and studied. When the selenium center was oxidized, the substituted Ph group undergoes π-π stacking with one side of the BODIPY core. The oxidized form showed, not only a down-field shift in the NMR peak, but also splitting due to geometrical changes that arise when going from C_s to C₁. The compound was characterized by X-ray diffraction; DFT methods helped elucidate the influence of the unexpected π-π stack and its connection to the photophys. properties imparted by the Se oxidation In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Computed Properties of C5H3BrOS).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Computed Properties of C5H3BrOS

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

cis-Annulation of an oxazoline fragment to levoglucosenone and the synthesis of 4-substituted 3-amino-1,6-anhydro-3-deoxy-β-D-mannopyranose was written by Sharipov, Bulat T.;Davidova, Anna N.;Valeev, Farid A.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2022.Related Products of 128-08-5 This article mentions the following:

Chiral 2-trichloromethyl-oxazolines 4,5-cis-annulated to a carbohydrate fragment were synthesized on the basis of levoglucosenone. The synthesized compounds were converted by acid hydrolysis into 4-substituted 3-amino-1,6-anhydro-3-deoxy-β-D-mannopyranoses. Intramol. amination of allyl trichloroacetimidates by electrophilic reagents was used to construct the oxazoline ring. It was established that trichloroacetimidates containing an epoxide ring in α,β-positions spontaneously undergo re-cyclization with the formation of an oxazoline ring. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Related Products of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Amino acid-promoted C-H alkylation with alkylboronic acids using a removable directing group was written by Zhang, Yu;Jiang, Hang;Chen, Dushen;Zhang, Yanghui. And the article was included in Organic & Biomolecular Chemistry in 2016.Category: bromides-buliding-blocks This article mentions the following:

Palladium-catalyzed C-H alkylation reaction with alkylboronic acids has successfully been developed using a removable pyridyldiisopropylsilyl directing group. The amino acid played a crucial role as a ligand in the reaction. The alkylation protocol is also applicable to the coupling of C(sp³)-H bonds with alkylboronic acids. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Category: bromides-buliding-blocks).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905) was written by Duffey, Matthew O.;Vos, Tricia J.;Adams, Ruth;Alley, Jennifer;Anthony, Justin;Barrett, Cynthia;Bharathan, Indu;Bowman, Douglas;Bump, Nancy J.;Chau, Ryan;Cullis, Courtney;Driscoll, Denise L.;Elder, Amy;Forsyth, Nancy;Frazer, Jonathan;Guo, Jianping;Guo, Luyi;Hyer, Marc L.;Janowick, David;Kulkarni, Bheemashankar;Lai, Su-Jen;Lasky, Kerri;Li, Gang;Li, Jing;Liao, Debra;Little, Jeremy;Peng, Bo;Qian, Mark G.;Reynolds, Dominic J.;Rezaei, Mansoureh;Scott, Margaret Porter;Sells, Todd B.;Shinde, Vaishali;Shi, Qiuju Judy;Sintchak, Michael D.;Soucy, Francois;Sprott, Kevin T.;Stroud, Stephen G.;Nestor, Michelle;Visiers, Irache;Weatherhead, Gabriel;Ye, Yingchun;D’Amore, Natalie. And the article was included in Journal of Medicinal Chemistry in 2012.Quality Control of 3-Nitro-4-(trifluoromethoxy)bromobenzene This article mentions the following:

This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chem. series produced an orally bioavailable inhibitor of PLK1 I (MLN0905). In vivo pharmacokinetic-pharmacodynamic experiments demonstrated prolonged mitotic arrest after oral administration of I to tumor bearing nude mice. A subsequent efficacy study in nude mice achieved tumor growth inhibition or regression in a human colon tumor (HT29) xenograft model. In the experiment, the researchers used many compounds, for example, 3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5Quality Control of 3-Nitro-4-(trifluoromethoxy)bromobenzene).

3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-Nitro-4-(trifluoromethoxy)bromobenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Steric effect of NHC ligands in Pd(II)-NHC-catalyzed non-directed C-H acetoxylation of simple arenes was written by Mandal, Tanmoy;Yadav, Sudha;Choudhury, Joyanta. And the article was included in Journal of Organometallic Chemistry in 2021.SDS of cas: 35065-86-2 This article mentions the following:

Herein, a series of well-defined discrete [Pd(NHCRR¹)(py)I₂] complexes I [R = Me, Cy, n-Bu, Mes; R¹ = Me, Cy, n-Bu, Mes, t-Bu, Ph; RR¹ = Me, Cy, n-Bu, Mes] with systematically varied degree of spatial congestion at the Pd center, exerted through the R and R¹ substituents on the NHC ligand, were explored in controlling the activity as well as the site-selectivity of non-directed acetoxylation of representative monosubstituted and disubstituted simple arenes (such as toluene, iodobenzene and bromobenzene, naphthalene and 1,2-dichlorobenzene). The resulting best yields were found to be 75% for toluene and 65% for bromobenzene with [Pd(NHCPhMe)(py)I₂], 75% for iodobenzene and 79% for naphthalene with [Pd(NHCMeMe)(py)I₂], and 41% for 1,2-dichlorobenzene with [Pd(NHCCyCy)(py)I₂]. Most importantly, with increasing the bulkiness of the NHC ligand in the complexes, the selectivity of the distal C-acetoxylated products in comparison to the proximal ones, was enhanced to a great extent in all cases. Considering the vast library of NHC ligands, this study underscores the future opportunity to develop more strategies to improve the activity and the crucial site-selectivity of C-H functionalization reactions in simple as well as complex organic mols. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2SDS of cas: 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.SDS of cas: 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cross-Coupling of Nonactivated Primary and Secondary Alkyl Halides with Aryl Grignard Reagents Catalyzed by Chiral Iron Pincer Complexes was written by Bauer, Gerald;Cheung, Chi Wai;Hu, Xile. And the article was included in Synthesis in 2015.Electric Literature of C9H11BrO This article mentions the following:

Iron(III) bisoxazolinylphenylamido (bopa) pincer complexes are efficient precatalysts for the cross-coupling of nonactivated primary and secondary alkyl halides with Ph Grignard reagents. The reactions proceed at room temperature in moderate to excellent yields. A variety of functional groups can be tolerated. The enantioselectivity of the coupling of secondary alkyl halides is low. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Electric Literature of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Visible-light-mediated conversion of alcohols to halides was written by Dai, Chunhui;Narayanam, Jagan M. R.;Stephenson, Corey R. J.. And the article was included in Nature Chemistry in 2011.Computed Properties of C10H13BrO This article mentions the following:

The development of new means of activating mols. and bonds for chem. reactions is a fundamental objective for chemists. In this regard, visible-light photoredox catalysis has emerged as a powerful technique for chemoselective activation of chem. bonds under mild reaction conditions. Here, the authors report a visible-light-mediated photocatalytic alc. activation, which the authors use to convert alcs. to the corresponding bromides and iodides in good yields, with exceptional functional group tolerance. In this fundamentally useful reaction, the design and operation of the process is simple, the reaction is highly efficient, and the formation of stoichiometric waste products is minimized. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Computed Properties of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Computed Properties of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary