Month: January 2023

Enhanced efficiency of polymer solar cells via simple fluorination on the π-bridge of polymer donors was written by Liao, Junxu;Weng, Fubiao;Zheng, Peijin;Xu, Gengbiao;Zeng, Langxian;Huang, Zhangen;Deng, Tianjiao;Pang, Yiqi;Wu, Siyang;Chen, Jianhao;Zhao, Hongbin;Xu, Yongjun. And the article was included in Organic Electronics in 2022.Formula: C4H4BrNO2 This article mentions the following:

In this contribution, a novel fluorinated polymer based on the well-known J52, using the newly developed 3-fluorothiophene as π bridges on the conjugated main chain, named J52-FTh, was synthesized and was used as polymer solar cells (PSCs) donor material. The effects of fluorinated π bridge on the polymer′s thermal stability, light absorption, energy level, mol. configuration and photovoltaic performance were systematically studied. It demonstrated that J52-FTh exhibited an enhanced absorption, a narrower optical band gap, a low-lying the highest occupied MOs (HOMO) energy level and better coplanar compared with J52 without any fluorine substituent on its π bridges. The non-fullerene PSCs based on J52-FTh:ITIC (1:0.8, weight/weight) achieved a high PCE of 13.32% with a V_OC of 0.92 V, a J_SC of 21.29 mA cm^-2 and an FF of 68%, which was much better than the PSCs based on J52:ITIC with a PCE of 5.51%. The results indicated that fluorination on the polymer′s main chain was a simple and efficient strategy toward high efficiency. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of 2-(3-aminophenyl)-benzothiazoles as antiproliferative and apoptosis-inducing agents was written by Zhang, Juan;Cheng, Zhi-Qiang;Song, Jia-Li;Tao, Hong-Rui;Zhu, Kongkai;Muehlmann, Luis Alexandre;Jiang, Cheng-Shi;Zhang, Hua. And the article was included in Monatshefte fuer Chemie in 2018.Synthetic Route of C7H5Br2F This article mentions the following:

A series of new 2-(3-aminophenyl)-benzothiazole derivatives were synthesized and evaluated for their in vitro antiproliferative activity against various human cancer cell lines including A549, HeLa, HepG2, MCF-7, MV4-11, and DB. Among the tested compounds, N-[3-(benzo[d]thiazol-2-yl)phenyl]nicotinamide displayed significantly improved antiproliferative activity toward A549 and MV4-11 cells with IC₅₀ values of 5.42±1.33 and 7.51±0.98 μM, resp., much stronger than the hit 3-(benzo[d]thiazol-2-yl)-N-(4-bromobenzyl)aniline. Furthermore, flow cytometric anal. indicated that N-[3-(benzo[d]thiazol-2-yl)phenyl]nicotinamide induced A549 cell apoptosis with cell cycle arrest at G1 phase in a concentration-dependent manner. Graphical abstract: [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Synthetic Route of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Sexithiophene-Bridged Cage Compound: A New Class of Three-Dimensionally Expanded Oligothiophenes was written by Adachi, Kazuhiko;Hirao, Yasukazu;Matsumoto, Kouzou;Kubo, Takashi;Kurata, Hiroyuki. And the article was included in Organic Letters in 2014.Computed Properties of C5H3BrOS This article mentions the following:

A bicyclo-type cage-shaped compound I [R = hexyl] consisting of three sexithiophenes was successfully synthesized and characterized by NMR, HRMS, and X-ray crystallog. anal. The strained cage architecture was reflected in the blue-shifted absorption spectrum relative to its linear analog. Intramol. interaction between three-dimensionally fixed sexithiophenes was suggested by electrochem. anal. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Computed Properties of C5H3BrOS).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C5H3BrOS

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Direct Primary Amination of Alkylmetals with NH-Oxaziridine was written by Behnke, Nicole Erin;Kielawa, Russell;Kwon, Doo-Hyun;Ess, Daniel H.;Kurti, Laszlo. And the article was included in Organic Letters in 2018.Product Details of 57293-19-3 This article mentions the following:

A method for the primary electrophilic amination of primary, secondary, and tertiary organometallic substrates from a bench-stable NH-oxaziridine reagent is described. This facile and highly chemoselective transformation occurs at ambient temperature and without transition metal catalysts or purification by column chromatog. to provide alkylamine products in a single step. D. functional theory (DFT) calculations revealed that, despite the basicity of alkylmetals, the direct NH-transfer pathway is favored over proton and O-transfer. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Product Details of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Asymmetric Reductive Arylalkylation of Unactivated Alkenes was written by Jin, Youxiang;Wang, Chuan. And the article was included in Angewandte Chemie, International Edition in 2019.Reference of 4457-67-4 This article mentions the following:

Reported is an asym. reductive dicarbofunctionalization of unactivated alkenes [e.g., 1-bromo-2-(3-methylbut-3-en-1-yl)benzene + 4-bromobutyl acetate �I (69%, 94% ee)]. Under the catalysis of a Ni/BOX system, various aryl bromides, incorporating a pendant olefinic unit, were successfully reacted with an array of primary alkyl bromides in the presence of Zn as a reductant, furnishing a series of benzene-fused cyclic compounds bearing a quaternary stereocenter in high enantioselectivities. Notably, this reaction avoids the use of pregenerated organometallics and demonstrates high tolerance of sensitive functionalities. The preliminary mechanistic investigations reveal that this Ni-catalyzed reaction proceeds as a cascade consisting of migratory insertion and cross-coupling with a nickel(I)-mediated intramol. 5-exo cyclization as the enantiodetermining step. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Reference of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Reference of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

No-Carrier-Added (4-Fluoro-3-[¹³¹I]iodobenzyl)guanidine and (3-[²¹¹At]Astato-4-fluorobenzyl)guanidine was written by Vaidyanathan, Ganesan;Affleck, Donna J.;Zalutsky, Michael R.. And the article was included in Bioconjugate Chemistry in 1996.SDS of cas: 452-62-0 This article mentions the following:

With 3-bromo-4-fluorotoluene as starting material, [4-fluoro-3-(trimethylsilyl)benzyl]guanidine was prepared in five steps in 1.5% overall yield. Radioiodination of this silicon precursor using N-chlorosuccinimide in trifluoroacetic acid at room temperature for 5 min gave (4-fluoro-3-[¹³¹I]iodobenzyl)guanidine ([¹³¹I]FIBG) in 50-60% radiochem. yield. A byproduct which had a retention time in two HPLC systems similar to that of (m-iodobenzyl)guanidine (MIBG) was formed in about 30% yield. [¹³¹I]FIBG was stable up to 3 h under these conditions of iodination, indicating that the byproduct is not generated as a result of [¹³¹I]FIBG degradation Using hydrogen peroxide as the oxidant in aqueous medium and a reaction time of 30 min at 50 °C, yields of [¹³¹I]FIBG could be increased to 75-80%, with less than 7% of the byproduct formed under these conditions. Astatination of the silicon precursor using N-chlorosuccinimide in trifluoroacetic acid at 70 °C gave 65-70% radiochem. yield of (3-[²¹¹At]astato-4-fluorobenzyl)guanidine ([²¹¹At]AFBG) in 10-15 min; about 17% of the byproduct formation was seen. Astatination of the silicon precursor under aqueous conditions using hydrogen peroxide was not successful. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0SDS of cas: 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.SDS of cas: 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A benzodithiophene-based semiconducting polymer for organic thin film transistor was written by Hong, Jung-A.;Kim, Ran;Yun, Hui-Jun;Park, Joung-Man;Shin, Sung Chul;Kim, Yun-Hi. And the article was included in Bulletin of the Korean Chemical Society in 2013.Recommanded Product: 18791-79-2 This article mentions the following:

Benzodithiophene based organic semiconducting polymer was designed and synthesized by stille coupling reaction. The structure of polymer was confirmed by NMR and IR. The weight average mol. weight (M_w) of polymer was 8,400 using GPC with polydispersity index of 1.4. The thermal, optical and electrochem. properties of polymer were characterized by TGA and DSC, UV-vis absorption and cyclic voltammetry. OTFT device using PBDT-10 exhibited the mobility of 7.2 × 10^-5 cm² V^-1 s^-1 and I_on/I_off of 2.41 × 10³. The film morphol. and crystallinity of PBDT-10, was studied using AFM and x-ray diffraction. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Recommanded Product: 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists was written by Hasui, Tomoaki;Matsunaga, Nobuyuki;Ora, Taiichi;Ohyabu, Norio;Nishigaki, Nobuhiro;Imura, Yoshimi;Igata, Yumiko;Matsui, Hideki;Motoyaji, Takashi;Tanaka, Toshimasa;Habuka, Noriyuki;Sogabe, Satoshi;Ono, Midori;Siedem, Christopher S.;Tang, Tony P.;Gauthier, Cassandra;De Meese, Lisa A.;Boyd, Steven A.;Fukumoto, Shoji. And the article was included in Journal of Medicinal Chemistry in 2011.Product Details of 58349-01-2 This article mentions the following:

Mineralocorticoid receptor (MR) blockade has come into focus as a promising approach for the treatment of cardiovascular diseases such as hypertension and congestive heart failure. In order to identify a novel class of nonsteroidal MR antagonists that exhibit significant potency and good selectivity over other steroidal hormone receptors, the authors designed a novel series of benzoxazin-3-one derivatives and synthesized them from 6-(7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-2H-1,4-benzoxazin-3(4H)-one (I), high-throughput screening (HTS) hit compound Their design was based on a crystal structure of an MR/compound complex and a docking model. In the course of lead generation from I, a 1,2-diaryl framework was characterized as a key structure with high binding affinity. On the basis of scaffold hopping and optimization studies, benzoxazin-3-one derivatives possessing 1-phenyl-3-trifluoromethylpyrazol-5-yl moiety at the 6-position were identified as a novel series of potent and selective MR antagonists. Among these compounds, 6-[1-(4-fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2H-1,4-benzoxazin-3(4H)-one (II) showed highly potent activity and good selectivity and also exhibited a significant antihypertensive effect in deoxycorticosterone acetate-salt hypertensive rats. On the basis of these results, compound II was progressed for further pharmacol. evaluation. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-chloro-6-nitrophenol (cas: 58349-01-2Product Details of 58349-01-2).

4-Bromo-2-chloro-6-nitrophenol (cas: 58349-01-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Product Details of 58349-01-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hierarchical self-assembly of supramolecular polymer complexes mediated by various generations of bent-core mesogenic dendrimers hydrogen-bonded with triblock copolymer was written by Lin, Chien-Min;Dwivedi, Atul Kumar;Chuang, Wei-Tsung;Lin, Hong-Cheu. And the article was included in Polymer in 2020.Category: bromides-buliding-blocks This article mentions the following:

A series of side-chain supramol. polymer complexes containing proton acceptor triblock copolymer, i.e., poly(4-vinylpyridine)-block-polystyrene-block-poly(4-vinylpyridine) (VSV, i.e., P4VP-PS-P4VP), hydrogen-bonded (H-bonded) with two generations of proton donor bent-core mesogenic dendritic pendants (G1 and G2) were prepared and investigated. These two supramol. polymer complexes (i.e., VSV/G1 and VSV/G2) were characterized by wide- and small-angle X-ray scattering (WAXS and SAXS), and the formation of a microphase separated smectic A (SmA) structure corresponding to a head-to-head layered arrangement was confirmed. The hierarchical structures within the morphologies of supramol. polymer complexes were proved not only by the SAXS patterns but also by the transmission electron microscopy (TEM). The novel hierarchical lamellar domains of corresponding tetragonal and hexagonal arrangements in different generations of dendritic proton donors (G1 and G2) were self-assembled with triblock copolymer proton acceptor VSV to induce resp. BCC (body-centered cubic) and FCC (face-centered cubic) structures in supramol. polymer complexes VSV/G1 and VSV/G2. Therefore, the shear alignments of characteristic cylindrical column phase micro-domains were developed for the first time to control the unique hierarchical constructions of functionalized self-assembled bent-core structures by utilization of various generations of dendritic proton donors to be H-bonded with triblock copolymer proton acceptor. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Category: bromides-buliding-blocks).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of trans-4-triazolyl-substituted 3-hydroxypiperidines was written by Harmsen, Rianne A. G.;Sydnes, Leiv K.;Tornroos, Karl W.;Haug, Bengt Erik. And the article was included in Synthesis in 2011.Application of 14425-64-0 This article mentions the following:

The synthesis of tert-Bu trans-4-ethynyl-3-hydroxypiperidine-1-carboxylate is described via regioselective ring-opening of a racemic N-Boc-protected 7-oxa-3-azabicyclo[4.1.0]heptane, and serves as a new scaffold for the preparation of substituted piperidines. The terminal alkyne is converted into 1,4- and 1,5-disubstituted 1,2,3-triazoles through 1,3-dipolar cycloaddition reactions with organic azides. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary