Month: January 2023

Total synthesis of dictyodendrins B and E, and formal synthesis of dictyodendrin C was written by Tao, Pengyu;Liang, Jingjing;Jia, Yanxing. And the article was included in European Journal of Organic Chemistry in 2014.Product Details of 14425-64-0 This article mentions the following:

A full account of the concise total syntheses of dictyodendrins B and E, and the formal synthesis of dictyodendrin C are described. A palladium-catalyzed Larock indole synthesis was used to form the highly substituted indole core, and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C-H activation reaction was used to construct the key pyrrolo[2,3-c]carbazole core. Unsuccessful synthetic strategies are also discussed. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Product Details of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A theoretical study on vibration frequencies of some aniline derivatives and correlations with experimental data was written by Rezaei-Sameti, M.. And the article was included in Asian Journal of Chemistry in 2010.Recommanded Product: 615-55-4 This article mentions the following:

A theor. study on the vibrational frequencies of all possible isomers of some aniline derivatives C₆H_5-nX_nNH₂ (n = 1-5; X = F, Cl, Br) is reported. Calculations were done at B3LYP employing the 6-31G(d), 6-31G(d,p), 6-31++G(d,p) and 6-311++G(d,p) levels of theory. The optimized structures were used for calculation of vibrational frequencies at B3LYP/6-311++G(d,p) level of theory. The resulting data were scaled by 0.952 for N-H stretching bond and 0.981 for C-N, C-X (X = F, Cl, Br), C=C, N-H (bending) bonds. There is a good agreement between the scaled theor. frequencies and exptl. data for this type of compounds In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Recommanded Product: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

syn-Selective alkylarylation of terminal alkynes via the combination of photoredox and nickel catalysis was written by Guo, Lei;Song, Fan;Zhu, Shengqing;Li, Huan;Chu, Lingling. And the article was included in Nature Communications in 2018.Reference of 179232-29-2 This article mentions the following:

An intermol., regio- and syn-stereoselective alkylarylation of terminal alkynes with tertiary alkyl oxalates via photoredox-Ni dual catalysis was described. This catalytic protocol, synergistically combining Ir/Ni-catalyzed alkyne difunctionalization with photoinduced alkene isomerization, afforded trisubstituted alkenes, e.g., I with excellent efficiency and syn-stereoselectivity. The mild conditions tolerated many functional groups, allowing for a broad scope with respect to terminal alkynes, aryl bromides, and alkyl oxalates. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Reference of 179232-29-2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 179232-29-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-Catalyzed Desilylative Acyloxylation of Silicon-Carbon Bonds on (Trimethylsilyl)arenes: Synthesis of Phenol Derivatives from Trimethylsilylarenes was written by Gondo, Keisuke;Oyamada, Juzo;Kitamura, Tsugio. And the article was included in Organic Letters in 2015.HPLC of Formula: 35065-86-2 This article mentions the following:

A strategy for desilylative acetoxylation of (trimethylsilyl)arenes has been developed in which (trimethylsilyl)arenes are converted into acetoxyarenes. The direct acetoxylation is performed in the presence of 5 mol % of Pd(OAc)₂ and PhI(OCOCF₃)₂ (1.5 equiv) in AcOH at 80 °C for 17 h. The acetoxyarenes are obtained in good to high yields (67-98%). The synthetic utility is demonstrated with a one-pot transformation of (trimethylsilyl)arenes to phenols by successive acetoxylation and hydrolysis. Furthermore, desilylative acyloxylation of 2-(trimethylsilyl)naphthalene using several carboxylic acids has been conducted. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2HPLC of Formula: 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and hypodentate Cu(II) complexes of new tripodal tetraamine ligands incorporating a long pendant arm was written by Lundin, Natasha J.;Hamilton, Ian G.;Blackman, Allan G.. And the article was included in Polyhedron in 2004.Related Products of 954-81-4 This article mentions the following:

The synthesis and characterization of the new aliphatic tripodal amine ligands apba (N-(5-aminopentyl)-N,N-bis(2-aminoethyl)amine) and ahba (N-(6-aminohexyl)-N,N-bis(2-aminoethyl)amine) are reported. The tetrahydrochloride salts of these ligands, as well as that of the previously reported ligand abba (N-(4-aminobutyl)-N,N-bis(2-aminoethyl)amine), react with CuCO₃·Cu(OH)₂ to give complexes in which the tripodal ligand coordinates to the Cu(II) ion in a hypodentate fashion, with the longest arm of the tripodal ligand remaining protonated and unbound in all cases. The crystal structure of [Cu(abbaH)Cl₂]Cl·2H₂O·MeOH reveals a five-coordinate Cu(II) ion in a slightly distorted square pyramidal geometry. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electronic interactions in phenyl acetates and acetanilides was written by Freedman, H. H.. And the article was included in Journal of the American Chemical Society in 1960.Related Products of 35065-86-2 This article mentions the following:

The infrared stretching frequency of CO increases in amides and esters of unsaturated alcs; this has been given 2 different interpretations, (a) inductive effect, by analogy with α-halo ketones, and (b) inhibition of contributing CO resonance forms. Evidence is presented for (a) being dominant in PhOAc (I), and (b) in PhNHAc (II). Uniplanar structures were found sterically hindered (Stuart Briegleb mol. models); the smallest admissible average angle between the acetyl and phenyl planes of I (II) is 60° (37.5°), and, therefore, the resonance energy retained from uniplanar contributions is only 25% (65%). Carbonyl absorption peaks are compared of I, II, and PhAc (III) with a m- or p-NO₂, CN, Br, Cl, Ac, CHO, OAc, NHAc, Ph, OMe, OH, NH₂, or Me substituents. Whereas the associated frequency shifts (Δ_ν) for II and III are linear with Hammett’s 6 constants, this is not observed for I; also, Δ_ν for electron-attracting substituents in p is twice as large in II as in I; all of which supports the proposed theory. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Related Products of 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regiospecific incorporation of bromine and iodine into phenols using (trimethylsilyl)phenol derivatives was written by Wilbur, D. S.;Stone, W. E.;Anderson, K. W.. And the article was included in Journal of Organic Chemistry in 1983.Computed Properties of C8H7BrO2 This article mentions the following:

An investigation of regiospecifically halogenating (and radiohalogenating) phenolic rings was carried out. The investigation used (trimethylsilyl)phenols, (trimethylsilyl)anisoles, and (trimethylsilyl)phenyl acetates as model compounds Brominations and iodinations of these compounds were carried out in MeOH or HOAc by generating the brominating agent (BrCl) or iodinating agent (ICl) in situ from the halide salts and N-chlorosuccinimide. None of the (trimethylsilyl)phenols yielded exclusive bromination by ipso substitution of the trimethylsilyl group. Of the (trimethylsilyl)anisoles, the ortho and para isomers gave regiospecific replacement of the trimethylsilyl group. All of the (trimethylsilyl)phenyl acetates yielded completely regiospecific incorporation of bromine and iodine by ipso substitution of the trimethylsilyl group. Yields of 80-90% were obtained for the halogenations (and radiohalogenations). In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Computed Properties of C8H7BrO2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Computed Properties of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Redox-active Magnetic Resonance Imaging Contrast Agents: Studies with Thiol-bearing 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetracetic Acid Derivatives was written by Jagadish, Bhumasamudram;Guntle, Gerald P.;Zhao, Dezheng;Gokhale, Vijay;Ozumerzifon, Tarik J.;Ahad, Ali M.;Mash, Eugene A.;Raghunand, Natarajan. And the article was included in Journal of Medicinal Chemistry in 2012.Electric Literature of C13H14BrNO2 This article mentions the following:

The synthesis and structure-activity relationships of a homologous series of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid gadolinium(III) complexes bearing thiol-terminated alkyl side chains from three to nine carbons in length are reported. The observed binding with human serum albumin (HSA) of the compounds having C-3 through C-7 side chain lengths was inhibited by homocysteine in a manner consistent with single-site binding. The observed binding with HSA of the compounds having C-8 and C-9 side chain lengths was only partly inhibited by homocysteine, consistent with multisite binding. The binding affinity of the C-7 compound could be related to the HSA oxidation state. 2D ¹H-¹H NMR TOCSY provided evidence of covalent binding of the europium analog of the C-6 compound to HSA-Cys³⁴. The longitudinal water-proton MRI relaxivities of the gadolinium complexes at 7 T increased upon binding to HSA. On the basis of these results, the C-6 and C-7 compounds were identified as promising redox-sensitive MRI contrast agents. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Electric Literature of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Antibacterial activities of fluorescent nano assembled triphenylamine phosphonium ionic liquids was written by Brunel, Frederic;Lautard, Christelle;Garzino, Frederic;Giorgio, Suzanne;Raimundo, Jean M.;Bolla, Jean M.;Camplo, Michel. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Recommanded Product: 1-Bromo-6-methoxyhexane This article mentions the following:

Staphylococcus aureus, a Gram pos. coccal bacterium is a major cause of nosocomial infection. We report the synthesis of new triphenylamine phosphonium ionic liquids which are able to self-assemble into multiwall nanoassemblies and to reveal a strong bactericidal activity (MIC = 0.5 mg/L) for Gram pos. bacteria (including resistant strains) comparable to that of standard antibiotics. Time kill, metabolism and fluorescence confocal microscopy studies show a quasi-instantaneously penetration of the nanoassemblies inside the bacteria resulting of a rapid blocking (30 min) of their proliferation. As confirmed by rezasurin reduction monitoring, these compounds strongly affect the bacterial metabolism and a Gram pos. vs. Gram neg. selectivity is clearly observed These fluorescent phosphonium ionic liquid might constitute a useful tool for both translocation studies and to tackle infectious diseases related to the field of implantol. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Recommanded Product: 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction was written by Macdonald, Jonathan D.;Chacon Simon, Selena;Han, Changho;Wang, Feng;Shaw, J. Grace;Howes, Jennifer E.;Sai, Jiqing;Yuh, Joannes P.;Camper, Demarco;Alicie, Bethany M.;Alvarado, Joseph;Nikhar, Sameer;Payne, William;Aho, Erin R.;Bauer, Joshua A.;Zhao, Bin;Phan, Jason;Thomas, Lance R.;Rossanese, Olivia W.;Tansey, William P.;Waterson, Alex G.;Stauffer, Shaun R.;Fesik, Stephen W.. And the article was included in Journal of Medicinal Chemistry in 2019.COA of Formula: C8H4BrF3O3 This article mentions the following:

The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction between MYC and its chromatin cofactor WD Repeat-Containing Protein 5. Blocking the association of these proteins is hypothesized to disrupt the localization of MYC to chromatin, thus disrupting the ability of MYC to sustain tumorigenesis. Utilizing a high-throughput screening campaign and subsequent structure-guided design, we identify small-mol. inhibitors of this interaction with potent in vitro binding affinity and report structurally related neg. controls that can be used to study the effect of this disruption. Our work suggests that disruption of this protein-protein interaction may provide a path toward an effective approach for the treatment of multiple tumors and anticipate that the mols. disclosed can be used as starting points for future efforts toward compounds with improved drug-like properties. In the experiment, the researchers used many compounds, for example, 3-Bromo-5-(trifluoromethoxy)benzoic acid (cas: 453565-90-7COA of Formula: C8H4BrF3O3).

3-Bromo-5-(trifluoromethoxy)benzoic acid (cas: 453565-90-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.COA of Formula: C8H4BrF3O3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary