Month: January 2023

Alkyloxime-Substituted Thiophene-Based Wide-Band-Gap Polymer Donor Achieving a High Short Circuit Current Density of 30 mA cm^-2 in Organic Solar Cells was written by Jiang, Yunsheng;Liu, Haitao;Li, Xu;Yuan, Yi;Wang, Jinliang;Cui, Bo;Li, Yuning. And the article was included in Chemistry of Materials in 2022.Synthetic Route of C4H4BrNO2 This article mentions the following:

A new polymer TTOTCl with a repeat unit consisting of a chlorinated thienyl-substituted benzo[1,2-b:4,5-b′]dithiophene (BDTCl) donor unit, a thiophene spacer, and an alkyloxime-substituted thiophene (TO) acceptor unit is reported as a wide-band-gap donor for nonfullerene acceptor-based organic solar cells (OSCs). The optical band gap (E_g^opt = 1.97 eV), the HOMO (HOMO) energy level (E_HOMO = -5.48 eV), and the LUMO (LUMO) energy level (E_LUMO = -3.51 eV) of TTOTCl match well with the nonfullerene acceptor Y6 (E_g^opt = 1.33 eV; E_HOMO = -5.65 eV; E_LUMO = -4.10 eV). TTOTCl also showed a high space charge-limited current (SCLC) hole mobility of 1.36 x 10^-3 cm² V^-1 s^-1. OSCs using TTOTCl as the donor and Y6 as the acceptor achieved a high power conversion efficiency (PCE) of up to 14.42% with a record high J_sc of 30.00 mA cm^-2 along with a V_oc of 0.70 V and a fill factor (FF) of 0.68. The PCE was further improved to 15.43% using a hole transport enhancement layer, with an enhanced V_oc and FF of 0.72 V and 0.71, resp. The unencapsulated OSC device showed excellent long-term stability in ambient air with a 90.4% retention in the PCE over 30 days. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Synthetic Route of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Synthetic Route of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore was written by Szalaj, Natalia;Bajda, Marek;Dudek, Katarzyna;Brus, Boris;Gobec, Stanislav;Malawska, Barbara. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2015.Application of 954-81-4 This article mentions the following:

Alzheimer’s disease (AD) is a fatal and complex neurodegenerative disorder for which effective treatment remains the unmet challenge. Using donepezil as a starting point, we aimed to develop novel potential anti-AD agents with a multidirectional biol. profile. We designed the target compounds as dual binding site acetylcholinesterase inhibitors, where the N-benzylamine pharmacophore is responsible for interactions with the catalytic anionic site of the enzyme. The heteroaromatic fragment responsible for interactions with the peripheral anionic site was modified and three different heterocycles were introduced: isoindoline, isoindolin-1-one, and saccharine. Based on the results of the pharmacol. evaluation, we identified compound 8b with a saccharine moiety as the most potent and selective human acetylcholinesterase inhibitor (IC₅₀ = 33 nM) and beta amyloid aggregation inhibitor. It acts as a non-competitive acetylcholinesterase inhibitor and is able to cross the blood-brain barrier in vitro. We believe that compound 8b represents an important lead compound for further development as potential anti-AD agent. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Application of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Functionalized congener approach to muscarinic antagonists: analogs of pirenzepine was written by Karton, Yishai;Bradbury, Barton J.;Baumgold, Jesse;Paek, Robert;Jacobson, Kenneth A.. And the article was included in Journal of Medicinal Chemistry in 1991.Name: N-(5-Bromopentyl)phthalimide This article mentions the following:

(Piperazinylacetyl)pyridobenzodiazepinones I [R = Me, H, Ac, Bz, etc.; R¹ = H, 8-SMe, 8-SO₂NH₂, 9-CH₂OH, etc.; R² = H, Et, (CH₂)₆CN] were prepared and examined as muscarinic receptor antagonists. Thus, 3-amino-2-chloropyridine underwent cyclocondensation with Me 2-aminobenzoate to give pyridobenzodiazepine II (R³ = H) which reacted with HOSO₂Cl followed by S-methylation to give II (R³ = SMe) (III). III condensed with ClCH₂COCl and 1-methylpiperazine to give I (R = Me, R¹ = 8-SMe, R² = H). Chain substitution at the C-8 or C-9 position essentially abolishes muscarinic receptor binding, whereas substitution of the endocyclic amide NH results in weak affinity. Further structure-activity relationship observations are discussed. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Name: N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

NIS/TBHP Induced Regioselective Selenation of (Hetero)Arenes via Direct C-H Functionalization was written by Ding, Chaochao;Yu, Yuanzu;Yu, Qiongli;Xie, Zixin;Zhou, Yan;Zhou, Jianmin;Liang, Guang;Song, Zengqiang. And the article was included in ChemCatChem in 2018.Related Products of 35065-86-2 This article mentions the following:

A simple and efficient method for the regioselective selenation of (hetero)arenes via direct C-H functionalization has been established using NIS and TBHP. The present protocol is compatible with different functional groups, and suitable for various (hetero)arenes and diselenides, efficiently affording the desired products in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Related Products of 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reactions of toluic acids and their derivatives with the system SF₄-HF-Br₂ was written by Madzhumder, U.;Kunshenko, B. V.;Yagupol’skii, L. M.. And the article was included in Ukrainskii Khimicheskii Zhurnal (Russian Edition) in 1998.Name: 1-Bromo-2-methyl-3-(trifluoromethyl)benzene This article mentions the following:

Reaction of toluic acid and its derivatives with sulfur tetrafluoride in anhydrous hydrogen fluoride in the presence of a halogenating agent has been studied, and it has been shown that in the presence of bromine in the system SF₄-HF-Br₂ yields of trifluoromethyl derivatives are abruptly increased. In these cases, the products contain from 1-3 atoms of bromine in the benzene ring. In the experiment, the researchers used many compounds, for example, 1-Bromo-2-methyl-3-(trifluoromethyl)benzene (cas: 69902-83-6Name: 1-Bromo-2-methyl-3-(trifluoromethyl)benzene).

1-Bromo-2-methyl-3-(trifluoromethyl)benzene (cas: 69902-83-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: 1-Bromo-2-methyl-3-(trifluoromethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 3-Trifluoromethyl-1,2,4-triazolines and 1,2,4-Triazoles via Tandem Addition/Cyclization of Trifluoromethyl N-Acylhydrazones with Cyanamide was written by Liu, Xiaoling;Liu, Haimei;Bian, Chang;Wang, Ke-Hu;Wang, Junjiao;Huang, Danfeng;Su, Yingpeng;Lv, Xiaobo;Hu, Yulai. And the article was included in Journal of Organic Chemistry in 2022.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

A tandem addition/cyclization reaction between trifluoromethyl N-acylhydrazones and cyanamide is described, which provides a novel and efficient process for the synthesis of polysubstituted 3-trifluoromethyl-1,2,4-triazolines and their derivatives The method has the advantages of mild reaction conditions, a broad substrate scope, good product yields, and atom economy. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application In Synthesis of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain was written by Sheppard, George S.;Wang, Le;Fidanze, Steven D.;Hasvold, Lisa A.;Liu, Dachun;Pratt, John K.;Park, Chang H.;Longenecker, Kenton;Qiu, Wei;Torrent, Maricel;Kovar, Peter J.;Bui, Mai;Faivre, Emily;Huang, Xiaoli;Lin, Xiaoyu;Wilcox, Denise;Zhang, Lu;Shen, Yu;Albert, Daniel H.;Magoc, Terrance J.;Rajaraman, Ganesh;Kati, Warren M.;McDaniel, Keith F.. And the article was included in Journal of Medicinal Chemistry in 2020.Related Products of 82702-31-6 This article mentions the following:

The BET family of proteins consists of BRD2, BRD3, BRD4, and BRDt. Each protein contains two distinct bromodomains (BD1 and BD2). BET family bromodomain inhibitors under clin. development for oncol. bind to each of the eight bromodomains with similar affinities. We hypothesized that it may be possible to achieve an improved therapeutic index by selectively targeting subsets of the BET bromodomains. Both BD1 and BD2 are highly conserved across family members (>70% identity), whereas BD1 and BD2 from the same protein exhibit a larger degree of divergence (~40% identity), suggesting selectivity between BD1 and BD2 of all family members would be more straightforward to achieve. Exploiting the Asp144/His437 and Ile146/Val439 sequence differences (BRD4 BD1/BD2 numbering) allowed the identification of compound 27 demonstrating greater than 100-fold selectivity for BRD4 BD2 over BRD4 BD1. Further optimization to improve BD2 selectivity and oral bioavailability resulted in the clin. development compound 46 (ABBV-744). In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Related Products of 82702-31-6).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 82702-31-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formation of substituted 1-naphthols and related products via dimerization of alkyl 3-(o-halo(het)aryl)-oxopropanoates based on a CuI-catalyzed domino C-arylation/condensation/aromatization process was written by Weischedel, Heike;Sudheendran, Kavitha;Mikhael, Alevtina;Conrad, Juergen;Frey, Wolfgang;Beifuss, Uwe. And the article was included in Tetrahedron in 2016.Formula: C8H6BrFO2 This article mentions the following:

Substrates bearing both a β-ketoester moiety and a (het)aryl halide structure element were dimerized to 1-naphthols and related products in the presence of catalytic amounts of CuI in isopropanol. The reaction starts with an intermol. C-arylation, which is followed by an intramol. condensation. The final aromatization delivers the highly substituted products with yields up to 81%. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Formula: C8H6BrFO2).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Formula: C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Solvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I₂ was written by Ding, Yuxin;Ma, Renchao;Ma, Yongmin. And the article was included in Tetrahedron Letters in 2021.COA of Formula: C24H15Br3 This article mentions the following:

A solvent-dependent I₂-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles I (R = H, Cl, Me; R¹ = H, Cl, Me; R² = Ph, 2-naphthyl, 3-thienyl, etc.) and 1,3,5-triarylbenzenes 1,3,5-(Ar)₃C₆H₃ (Ar = Ph, 2-naphthyl, 3-thienyl, etc.) via the annulation of 2-amino anilines 1,2-(NH₂)₂-4-R-5-R¹C₆H₂ and aryl alkyl ketones R²C(O)Me or the cyclization of aryl alkyl ketones ArC(O)Me, resp. With 1,4-dioxane as the solvent, sequential C-N bond formation followed by C(CO)-C(CH₃) bond cleavage leads to the formation of benzimidazoles I in a highly selective manner while aldol-type self-condensation of aryl alkyl ketones predominates using PhNO₂ or PhCl as the solvent to afford 1,3,5-triarylbenzenes. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2COA of Formula: C24H15Br3).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C24H15Br3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

8-Substituted pteridines was written by Dick, G. P. G.;Fidler, W. E.;Wood, H. C. S.. And the article was included in Chemistry & Industry (London, United Kingdom) in 1956.Electric Literature of C5H11BrO This article mentions the following:

Preparations of 8-substituted pteridines from pyrazine intermediates were studied. 2-Hydroxy-3-methoxycarbonylpyrazine in Me₂CO solution with MeI in the presence of K₂CO₃ gave 1,2-dihydro-3-methoxycarbonyl-1-methyl-2-oxopyrazine (I). I with guanidine carbonate in aqueous MeOH gave a salt of guanidine and 1,2-dihydro-1-methyl-2-oxopyrazine-3-carboxylic acid, which had phys. properties similar to those expected for 2,8-dihydro-4-hydroxy-2-imino-8-methylpteridine. Fusion of 1,2-dihydro-3-methoxycarbonyl-1-methyl-2-oxo-5,6-diphenylpyrazine with guanidine carbonate gave 93% 2,8-dihydro-4-hydroxy-2-imino-8-methyl-6,7-diphenylpteridine. This method is applicable to preparations of pteridines with a sugar group at the 8 position. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Electric Literature of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary