Month: January 2023

The synthesis and complexation properties of multidentate per-[6-deoxy-6-thio-(4-pyridyl)]-cyclodextrins was written by Chmurski, Kazimierz;Jurczak, Janusz;Coleman, Anthony W.. And the article was included in Journal of Coordination Chemistry in 1999.Recommanded Product: 53784-83-1 This article mentions the following:

The synthesis of chem. modified multidentate cyclodextrins capable of carrying pyridyl ligands is reported. Per-(6-bromo-6-deoxy)-α-, -β-, and -γ-cyclodextrins were treated with an excess of 4-mercaptopyridine affording per-[6-deoxy-thio-6-(4-pyridyl)]-α-, -β-, and -γ-cyclodextrin derivatives in very high yields (90-95% for isolated products). The solubilities of such systems in non-aqueous solvents were efficiently increased by acetylation of the secondary hydroxyl groups. The complexation properties of the derivatives with regard to copper(II) were investigated by solvent extraction, ESR and spectroscopic titration experiments In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Recommanded Product: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Halogenation using quaternary ammonium polyhalides. XXIII. Bromination of aromatic amines with polymer-bound benzyltrimethylammonium tribromide was written by Okamoto, Tsuyoshi;Kakinami, Takaaki;Kusumoto, Masao;Yonemaru, Satoshi;Kajigaeshi, Shoji. And the article was included in Nippon Kagaku Kaishi in 1990.Electric Literature of C7H7BrN2O2 This article mentions the following:

Bromo-substituted aromatic amines were obtained quant. by passing a solution of aromatic amines in dichloromethane-methanol through a column packed with styrene polymer-bound benzyltrimethylammonium tribromide. E.g., 2,4,6-tribromoaniline (I) was obtained in 99% yield from aniline. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Electric Literature of C7H7BrN2O2).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Electric Literature of C7H7BrN2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of a Potent Sodium Hydrogen Exchanger Isoform 1 (NHE1) Inhibitor with a Suitable Profile for Chronic Dosing and Demonstrated Cardioprotective Effects in a Preclinical Model of Myocardial Infarction in the Rat was written by Huber, John D.;Bentzien, Jorg;Boyer, Stephen J.;Burke, Jennifer;De Lombaert, Stephane;Eickmeier, Christian;Guo, Xin;Haist, James V.;Hickey, Eugene R.;Kaplita, Paul;Karmazyn, Morris;Kemper, Raymond;Kennedy, Charles A.;Kirrane, Thomas;Madwed, Jeffrey B.;Mainolfi, Elizabeth;Nagaraja, Nelamangara;Soleymanzadeh, Fariba;Swinamer, Alan;Eldrup, Anne B.. And the article was included in Journal of Medicinal Chemistry in 2012.Formula: C9H6BrF3O2 This article mentions the following:

Sodium-hydrogen exchanger isoform 1 (NHE1) is a ubiquitously expressed transmembrane ion channel responsible for intracellular pH regulation. During myocardial ischemia, low pH activates NHE1 and causes increased intracellular calcium levels and aberrant cellular processes, leading to myocardial stunning, arrhythmias, and ultimately cell damage and death. The role of NHE1 in cardiac injury has prompted interest in the development of NHE1 inhibitors for the treatment of heart failure. This report outlines our efforts to identify a compound suitable for once daily, oral administration with low drug-drug interaction potential starting from NHE1 inhibitor sabiporide. Substitution of a piperidine for the piperazine of sabiporide followed by replacement of the pyrrole moiety and subsequent optimization to improve potency and eliminate off-target activities resulted in the identification of N-[4-(1-acetyl-piperidin-4-yl)-3-trifluoromethylbenzoyl]guanidine (I). Pharmacol. evaluation of I revealed a remarkable ability to prevent ischemic damage in an ex vivo model of ischemia reperfusion injury in isolated rat hearts. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8Formula: C9H6BrF3O2).

Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C9H6BrF3O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Thermal Redox Functionalization of C(sp³)-H Bonds with Carbon Electrophiles was written by Gong, Yuxin;Su, Lei;Zhu, Zhaodong;Ye, Yang;Gong, Hegui. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: 128-08-5 This article mentions the following:

A Ni-catalyzed arylation and alkylation of C(sp₃)-H bonds with organohalides to forge C(sp₃)-C bonds by merging economical Zn and tBuOOtBu (DTBP) as the external reductant and oxidant was reported. The mild and easy-to-operate protocol enabled facile carbofunctionalization of N-/O-α- and cyclohexane C-H bonds, and preparation of a few intermediates of bioactive compounds and drug derivatives Preliminary mechanistic studies implied addition of an alkyl radical to a NiII salt. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Asymmetric phase-transfer catalysis of homo- and heterochiral quaternary ammonium salts: development and application of conformationally flexible chiral phase-transfer catalysts was written by Ooi, Takashi;Uematsu, Yukitaka;Kameda, Minoru;Maruoka, Keiji. And the article was included in Tetrahedron in 2006.Formula: C9H11Br This article mentions the following:

Inspired by the considerable difference of catalytic activity and stereocontrolling ability between the conformationally rigid, homo- and heterochiral quaternary ammonium bromides 1 (I), conformationally flexible, N-spiro chiral quaternary ammonium bromides of type 4 (II) have been designed and synthesized. Reliable procedures for the preparation of the appropriately substituted biphenyl subunits have been established by the repeated use of ortho magnesiation-halogenation as a key synthetic tool. The relationship between the structure of achiral biphenyl moiety and the reactivity and selectivity of 4 has been evaluated in the asym. alkylation of glycinate Schiff base 2 (III) under typical phase-transfer conditions, leading to the identification of 4l (Ar¹ = 3,5,-Ph₂-C₆H₃) as an optimal catalyst structure to exhibit an excellent enantiocontrol in the reactions with various alkyl halides. The mol. structure of 4l was determined by X-ray crystallog. anal. and its unique behavior in solution was examined by a variable-temperature ¹H NMR study. These investigations uncovered that the observed high chiral efficiency originated from the efficient asym. phase-transfer catalysis of homochiral-4l, which rapidly equilibrated with heterochiral-4l of low catalytic activity and stereoselectivity. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Formula: C9H11Br).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Formula: C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Polymer Chromophore-Catalyst Assembly for Solar Fuel Generation was written by Jiang, Junlin;Sherman, Benjamin D.;Zhao, Yan;He, Ru;Ghiviriga, Ion;Alibabaei, Leila;Meyer, Thomas J.;Leem, Gyu;Schanze, Kirk S.. And the article was included in ACS Applied Materials & Interfaces in 2017.SDS of cas: 22426-14-8 This article mentions the following:

A polystyrene-based chromophore-catalyst assembly (poly-2) has been synthesized and assembled at a mesoporous metal oxide photoanode. The assembly contains water oxidation catalyst centers based on [Ru(trpy) (phenq)]²⁺ (Ru-Cat) and [Ru(bpy)₃]²⁺ derivatives (Ru-C) as chromophores (trpy= 2,2′;6,2”- terpyridine, phenq = 2-(quinol-8′-yl)-1,10-phenanthroline and bpy = 2,2′-bipyridine). The photophys. and electrochem. properties of the polychromophore-oxidation catalyst assembly were investigated in solution and at the surface of mesoporous metal oxide films. The layer-by-layer (LbL) method was utilized to construct multilayer films with cationic poly-2 and anionic poly(acrylic acid) (PAA) for light-driven photochem. oxidations Photocurrent measurements of (PAA/poly-2)₁₀ LbL films on mesoporous TiO₂ demonstrate light-driven oxidation of phenol and benzyl alc. in aqueous solution Interestingly, illumination of (PAA/poly-2)₅ LbL films on a fluorine doped SnO₂/TiO₂ core/shell photoanode in aqueous solution gives rise to an initial photocurrent (âˆ?8.5 μA·cm^-2) that is in part ascribed to light driven water oxidation In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8SDS of cas: 22426-14-8).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.SDS of cas: 22426-14-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed migratory alkyl-alkyl cross-coupling reaction was written by Li, Yangyang;Li, Yuqiang;Peng, Long;Wu, Dong;Zhu, Lei;Yin, Guoyin. And the article was included in Chemical Science in 2020.SDS of cas: 14425-64-0 This article mentions the following:

A migratory cross-coupling strategy, which can overcome this obstacle to access the desired cross-coupling products ArCH(R)(CH₂)_nCR¹R²R³ (Ar = Ph, 4-fluorophenyl, indol-3-yl, etc.; R = cyclopentyl, cyclohexyl, cycloheptyl, N-benzyl-piperidin-4-yl, 2-methyl-propan-1-yl; R¹ = H, D; R² = H, D; R³ = H; n = 0-3, 5), 1-cyclopentyl-indan, 1-cycloheptyl-indan, (1-cyclopentyl-3-methyl-pentyl)benzene was described. Accordingly, a selective migratory cross-coupling of two alkyl electrophiles (RBr, ArCH(R)(CH₂)_nCR¹R²R³ (R³ = Br or Cl), 2-bromoindan, (5-bromo-1-cyclopentyl-3-methyl-pentyl)benzene) has been accomplished by nickel catalysis. Remarkably, this alkyl-alkyl cross-coupling reaction provides a platform to prepare 2°-2° carbon-carbon bonds from 1° and 2° carbon coupling partners. Preliminary mechanistic studies suggest that chain-walking occurs at both alkyl halides in this reaction, thus a catalytic cycle with the key step involving two alkylnickel(II) species is proposed for this transformation. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0SDS of cas: 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.SDS of cas: 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-catalyzed endo-type trifluoromethylarylation of alkynes was written by Xu, Jun;Wang, Yun-Long;Gong, Tian-Jun;Xiao, Bin;Fu, Yao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Product Details of 14425-64-0 This article mentions the following:

A new copper-catalyzed trifluoromethylarylation reaction of alkynes has been developed. The transformation represents the first example of endo-type carbotrifluoromethylation of unsaturated carbon-carbon bonds and provides efficient access to a variety of CF₃-substituted dihydronaphthalenes and chromenes. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Product Details of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Product Details of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The first chiral HPLC separation of dicarba-nido-undecarborate anions and their chromatographic behavior was written by Horacek, Ondrej;Papajova-Janetkova, Monika;Gruner, Bohumir;Lochman, Lukas;Sterbova-Kovarikova, Petra;Vespalec, Radim;Kucera, Radim. And the article was included in Talanta in 2021.Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

Boron cluster compounds are extensively studied due to their possible use in medicinal chem., mainly in the boron neutron capture anticancer therapy and as new innovative pharmacophores. Concerning this research, the chiral separations of exceptionally stable anionic 7,8-dicarba-nido-undecaborate(1-) and metal bis(dicarbollide)(1-) derivatives with asym. substitutions remain the unsolved challenge of the chiral chromatog. nowadays. Although the successful enantioseparation of some anionic 7,8-dicarba-nido-undecaborate(1-) ion derivatives were achieved in CZE with native β-cyclodextrins, it has not been observed with HPLC, yet. This study aimed to systematically investigate the enantioseparation of selected compounds in HPLC using native β-cyclodextrin and brominated β-cyclodextrin. The findings revealed pos. charged strong adsorption sites on a stationary phase, identified as the cationic metal impurities in the silica-gel backbone. All the anionic species under the study were at least partially enantiosepd. when a chelating agent blocked these cationic sites. Consequently, the first-ever HPLC enantioseparations of the 7,8-dicarba-nido-undecaborates(1-) were achieved. The brominated β-cyclodextrin seemed to be a better chiral selector for separation of these species, whereas the native β-cyclodextrin separated the anionic cobalt bisdicarbollide(1-). The results of this study bring new information concerning the chiral separation of anionic boron clusters and might be used in the chiral method development process on other chiral selectors. Furthermore, the possibility of chiral separation of these species could influence the ongoing research areas of anionic boron clusters. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The hydrolysis of carboxylic anhydrides. IV. Succinic and tetramethylsuccinic anhydrides was written by Bunton, C. A.;Fendler, J. H.;Fuller, N. A.;Perry, S.;Rocek, J.. And the article was included in Journal of the Chemical Society in 1963.Related Products of 2178-24-7 This article mentions the following:

Hydrolysis of succinic and tetramethylsuccinic anhydride is retarded by aqueous mineral acids (except for dilute H₂SO₄ and HCl). It is acid-catalyzed in aqueous dioxane. Hydrolysis of succinic anhydride in water is accelerated by bivalent electrolytes, but retarded by univalent electrolytes (except for NaHSO₄). In water the feeble catalysis by protons is opposed by a sp. neg. salt effect, but the rate in aqueous acid is always greater than that in solutions of the alkali-metal salts. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Related Products of 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary