Month: January 2023

Synthesis of symmetrical cyclodextrin derivatives bearing multiple charges was written by Guillo, Frederique;Hamelin, Bertrand;Jullien, Ludovic;Canceill, Josette;Lehn, Jean-Marie;De Robertis, Laurence;Driguez, Hugues. And the article was included in Bulletin de la Societe Chimique de France in 1995.Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

Several water-soluble sym. cyclodextrin derivatives bearing pos. charged or neg. charged groups were synthesized to examine the possibility of obtaining stable electrostatically linked hetero-dimers in water. The pos. charged species were obtained from per-amino functionalization of the 6-glucose positions, whereas the neg. units were obtained through introduction of thioglycolate or glycolate groups at the 6- or 3-glucose positions. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-Catalyzed Enantioselective C(sp²)-H Imidoylation by Desymmetrization was written by Wang, Jian;Gao, De-Wei;Huang, Jinbo;Tang, Shi;Xiong, Zhuang;Hu, Huaanzi;You, Shu-Li;Zhu, Qiang. And the article was included in ACS Catalysis in 2017.Recommanded Product: 61150-57-0 This article mentions the following:

An efficient palladium-catalyzed enantioselective isocyanide insertion/desymmetrizing C(sp²)-H bond activation reaction allowed by a SPINOL-derived phosphoramidite ligand was developed. 3,4-Dihydroisoquinolines containing C3 quaternary stereogenic centers, e.g., I, were obtained in high yields with good enantioselectivity under mild conditions. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Recommanded Product: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Structure-Activity Relationship Study of Novel Indole-2-carboxamide Derivatives as Anti-inflammatory Agents for the Treatment of Sepsis was written by Liu, Zhiguo;Tang, Longguang;Zhu, Heping;Xu, Tingting;Qiu, Chenyu;Zheng, Suqing;Gu, Yugui;Feng, Jianpeng;Zhang, Yali;Liang, Guang. And the article was included in Journal of Medicinal Chemistry in 2016.Product Details of 83902-02-7 This article mentions the following:

Sepsis is characterized by a systemic inflammatory response syndrome. Derivatives of indole have been reported to exhibit diverse biol. activities. This study reports on the design and synthesis of a new series of indole-2-carboxamide derivatives, which are screened for their anti-inflammatory activities in RAW 264.7 macrophages. A majority of these derivatives effectively inhibited lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Preliminary structure-activity relationship anal. was also conducted. The results indicate that the most promising compounds in the prepared series were 14f and 14g. They were found to effectively reduce LPS-induced pulmonary inflammation and overexpression of a series of inflammatory mediators. Furthermore, in vivo administration of 14f and 14g resulted in remarkable lung histopathol. improvements in mice without toxicity in organs. Taken together, these data indicate that the newly discovered indole-2-carboxamide derivatives could be particularly useful for further treatment in inflammatory diseases. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Product Details of 83902-02-7).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Product Details of 83902-02-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Silver complexes [Ph₃PCH₂CH₂PPh₃]²⁺[Ag₂Cl₄]^2-, [Ph₃PCH₂OCH₃]⁺₂[Ag₂Cl₄]^2-, [Ph₃P(i-Am)]⁺₂[Ag₂Br₄]^2-, [Ph₃PC₆H₁₁-cyclo]⁺₂[Ag₂Br₄]^2-, [Ph₃PCH₂Ph]⁺₂[Ag₂Br₄]^2-, and [Ph₃PCH:CH₂]⁺_n[Ag₂Br₃]^–_n, [Me₄P]⁺_n[Ag₂Br₃]^–_n: Synthesis and structure was written by Sharutin, V. V.;Sharutina, O. K.;Senchurin, V. S.;Neudachina, A. N.. And the article was included in Russian Journal of Inorganic Chemistry in 2016.Recommanded Product: Isopentyltriphenylphosphonium bromide This article mentions the following:

Silver complexes [Ph₃PCH₂CH₂PPh₃]²⁺[Ag₂Cl₄]^2- (1), [Ph₃PCH₂OCH₃]⁺₂[Ag₂Cl₄]^2- (2), [Ph₃P(i-Am)]⁺₂[Ag₂Br₄]^2- (3), [Ph₃PC₆H₁₁-cyclo]⁺₂[Ag₂Br₄]^2- (4), [Ph₃PCH₂Ph]⁺₂[Ag₂Br₄]^2- (5), [Ph₃PCH:CH₂]_n⁺[Ag₂Br₃]_n^n- (6), and [Me₄P]_n⁺[Ag₂Br₃]_n^n- (7) have been synthesized by the reaction between tetraorganylphosphonium halides and silver chloride or silver bromide in dimethylsulfoxide. According to x-ray diffraction data, the ionic complexes are built of tetraorganylphosphonium cations and binuclear (1–5) or polynuclear (6, 7) anions. In the anions of complexes 6 and 7, silver atoms are tetracoordinated, and bromine atoms have coordination numbers of 2 and 4. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Recommanded Product: Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Length Effect of Alkyl Linkers on the Crystalline Transition in Naphthalene Diimide-Based Double-Cable Conjugated Polymers was written by Hu, Zhijie;Xiao, Chengyi;Tan, Wen Liang;Liu, Baiqiao;Liang, Shijie;Jiang, Xudong;McNeil, Christopher R.;Li, Weiwei. And the article was included in Macromolecules (Washington, DC, United States) in 2022.Synthetic Route of C7H15BrO This article mentions the following:

The alkyl chains as linkers in double-cable conjugated polymers play an important role in the solubility, packing motif, morphol., and voltage loss in single-component organic solar cells (SCOSCs). In this work, we incorporate alkyl linkers with lengths from hexyl (C₆H₁₂) to hexadecyl (C₁₆H₃₂) into naphthalene diimide-based double-cable conjugated polymers. These polymers show a parabolic-type distribution in crystallinity, in which the crystalline degree of the polymers is enhanced in sequence from P06 (C₆H₁₂ linker) to P12 (C₁₂H₂₄ linker) and then decreased in longer alkyl linkers. These differences bring into deviations like optical bandgaps, packing motif, charge transport, and photovoltaic performance in SCOSCs. This work demonstrates the importance of linkers’ length on crystallinity and packing motif as well as provides a new viewpoint in guiding the design of new double-cable conjugated polymers. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Synthetic Route of C7H15BrO).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C7H15BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids was written by Jiao, Ke-Jin;Ma, Cong;Liu, Dong;Qiu, Hui;Cheng, Bin;Mei, Tian-Sheng. And the article was included in Organic Chemistry Frontiers in 2021.Related Products of 14425-64-0 This article mentions the following:

A highly regioselective Ni-catalyzed electrochem. (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides was developed. This strategy allowed the direct acylation of benzylic C(sp³)-H bonds in good yields from com. available alkyl carboxylic acids, thus provided an alternative strategy for the synthesis of dialkyl ketones. Various functional groups were tolerated under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Related Products of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structurally Informative Isotopic Shifts in Ion Mobility Spectra for Heavier Species was written by Pathak, Pratima;Baird, Matthew A.;Shvartsburg, Alexandre A.. And the article was included in Journal of the American Society for Mass Spectrometry in 2020.HPLC of Formula: 615-55-4 This article mentions the following:

The isotopic mol. envelopes due to stable isotopes for most elements were a staple of mass spectrometry since its origins, often leveraged to identify and quantify compounds However, all isomers share one MS envelope. As the mol. motion in media also depends on the isotopic composition, separations such as liquid chromatog. (LC) and ion mobility spectrometry (IMS) must also feature isotopic envelopes. These were largely not observed because of limited resolution, except for the (structurally uninformative) shifts in LC upon H/D exchange. We recently found the isotopic shifts in FAIMS for small haloanilines (∼130-170 Da) to hinge on the halogen position, opening a novel route to isomer characterization. Here, we extend the capability to heavier species: dibromoanilines (DBAs, ∼250 Da) and tribromoanilines (TBAs, ∼330 Da). The ¹³C shifts for DBAs and TBAs vary across isomers, some changing sign. While ⁸¹Br shifts are less specific, the 2-D ¹³C/⁸¹Br shifts unequivocally differentiate all isomers. The trends for DBAs track those for dichloroanilines, with the ¹³C shift order preserved for most isomers. The peak broadening due to merged isotopomers is also isomer-specific. The absolute shifts for TBAs are smaller than those for lighter haloanilines, but differentiate isomers as well because of compressed uncertainties. These results showcase the feasibility of broadly distinguishing isomers in the more topical ∼200-300 Da range using the isotopic shifts in IMS spectra. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4HPLC of Formula: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Field-Assisted Alignment of Self-Assembled Fibers Composed of Hydrogen-Bonded Molecules Having Laterally Fluorinated Mesogens was written by Yoshio, Masafumi;Shoji, Yoshiko;Tochigi, Yusuke;Nishikawa, Yohei;Kato, Takashi. And the article was included in Journal of the American Chemical Society in 2009.Reference of 954-81-4 This article mentions the following:

Aligned fibrous aggregates of amide compounds having laterally fluorinated aromatic mesogens have been successfully obtained by the application of the a.c. elec. field (1.0 V/μm, 1 kHz) in dodecylbenzene. In contrast, randomly entangled fibers are formed in the solvent without elec. fields. For the analogous compounds without fluorine substituent, no aligned fibrous aggregates have been obtained under the elec. fields. The elec. field alignment of the fibers should be assisted by the fluorinated rod-shaped mesogens that exhibit neg. dielec. anisotropy. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Reference of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Reference of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chelation-assisted de-aryloxylative amination of 2-aryloxy quinolines: a new synthetic route to a key fragment of a bioactive PRMT5 inhibitor was written by Gupta, Aniket;Kumar, Jogendra;Bhadra, Sukalyan. And the article was included in Organic & Biomolecular Chemistry in 2018.Category: bromides-buliding-blocks This article mentions the following:

A highly regioselective de-aryloxylative amination of O- or N-chelating group-functionalized 2-aryloxy quinolines was accomplished by means of a copper catalyst. The chelating functional groups of the substrate played a crucial role in directing the C-2-selective amination process, which was proceeded through a novel aromatic nucleophilic substitution of the aryloxy group. The methodol. provided expedient access to an important class of functionalized 2-aminoquinolines I [R = NMe₂, piperidinyl, N(Bn)₂, etc.; R¹ = H, 5-F, 5-Cl, 5-Br, 5-Me, 5-OMe; R² = OH, NHTs, NHC(O)Me, etc.] (up to 88% isolated yield) and was successfully applied for the synthesis of a key fragment of an important bioactive PRMT5 inhibitor I [R = morpholinyl; R¹ = H; R² = OCH₂C(O)OEt]. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Category: bromides-buliding-blocks).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary