Month: January 2023

Smectic-Layer Alignments of Surface-Modified Gold Nanoparticles in the Nanocomposite Induced by a Hydrogen-Bonded Bent-Core Liquid Crystalline Host under Electric Fields was written by Chen, Wei-Hong;Chang, Yi-Ting;Lee, Jey-Jau;Chuang, Wei-Tsung;Lin, Hong-Cheu. And the article was included in Chemistry – A European Journal in 2011.Name: 3-Bromophenyl acetate This article mentions the following:

The layer spacing (TEM image) of 5.5 nm of the nanocomposite comprising an H-bonded bent-core LC host and surface modified Au NPs presenting a covalently bonded bent-core surfactant under DC/AC elec. fields perfectly matches the d spacing of 5.5 nm obtained by in situ XRD measurements under a DC elec. field. TEM images revealed that the well-organized packing of layers of surface-modified gold NPs could be induced in the nanocomposite under elec. fields. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Name: 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Name: 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

β-Cyclodextrin-Derived Monolithic, Hierarchically Porous Polyimides Designed for Versatile Molecular Separation Applications was written by Leonhardt, Eric E.;Meador, Mary Ann B.;Wooley, Karen L.. And the article was included in Chemistry of Materials in 2018.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

This work details the development of a chem. resistant, porous polyimide derived from β-cyclodextrin, pairing the interesting and unique sorption properties of cyclodextrins with the chem. robustness of polyimides to create versatile monolithic, porous frameworks. Cyclodextrin-based materials have achieved great notoriety, recently, for their utility in separation processes, such as in the near-instant removal of organic contaminants from wastewater streams and in the capture of odorous compounds from air, due to the unique ability of the cyclodextrins to reversibly bind guest mols. in their cyclic cavities. Inclusion of cyclodextrins as active host systems within a porous framework is crucial for their accessibility to enhance their performance in separation applications, relative to nonporous materials. However, the current generation of porous materials typically require long reaction times and yield insoluble powders that severely limit their use. The technol. presented herein offers a novel, scalable solution to the preparation of porous cyclodextrin-derived materials, and further increases their utility by enabling diverse applications through mold and film casting. Here, the authors demonstrate their rapid synthesis and processing, their inherent hierarchical porosity, their extraordinary chem. stability, and their efficacy as regenerable sorbents with powerful potential for a wide range of separation applications. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Quality Control of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lateral substituted phenyl biphenylcarboxylates – non-chiral analogues of ferroelectric liquid crystals was written by Cigl, Martin;Jurok, Radek;Hampl, Frantisek;Svoboda, Jiri;Podoliak, Natalia;Novotna, Vladimira. And the article was included in Liquid Crystals in 2020.Safety of Methyl 4-bromo-2-fluorobenzoate This article mentions the following:

In this study mesomorphic properties of non-chiral liquid crystalline mols. and study the effect of lateral halogen (fluoro, chloro) substitution in the mol. core and the length of terminal chains was reported. This study prepared nine homolog series with the mol. core substituted at different positions with respect to the ester linkage group. Addnl., this study modified the length of both terminal alkyl chains (hexyl, octyl, decyl and dodecyl) sym. for both terminal chains. The effects of the lateral substitution and the chain length were analyzed with respect of the possibility to reduce the transition temperatures and tune the properties of presented liquid crystalline mols. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Safety of Methyl 4-bromo-2-fluorobenzoate).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of Methyl 4-bromo-2-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines was written by Wichitnithad, Wisut;O’Callaghan, James P.;Miller, Diane B.;Train, Brian C.;Callery, Patrick S.. And the article was included in Bioorganic & Medicinal Chemistry in 2011.Computed Properties of C9H11BrO This article mentions the following:

A novel class of N-substituted tetrahydropyridine derivatives was found to have multiple kinetic mechanisms of monoamine oxidase A inhibition. Eleven structurally similar tetrahydropyridine derivatives were synthesized and evaluated as inhibitors of MAO-A and MAO-B. The most potent MAO-A inhibitor in the series, 2,4-dichlorophenoxypropyl analog 12, displayed time-dependent mixed noncompetitive inhibition. The inhibition was reversed by dialysis, indicating reversible enzyme inhibition. Evidence that the slow-binding inhibition of MAO-A with 12 involves a covalent bond was gained from stabilizing a covalent reversible intermediate product by reduction with sodium borohydride. The reduced enzyme complex was not reversible by dialysis. The results are consistent with slowly reversible, mechanism-based inhibition. Two tetrahydropyridine analogs that selectively inhibited MAO-A were characterized by kinetic mechanisms differing from the kinetic mechanism of 12. As reversible inhibitors of MAO-A, tetrahydropyridine analogs are at low risk of having an adverse effect of tyramine-induced hypertension. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly diastereoselective synthesis of tetralin-fused spirooxindoles via Lewis acid-catalyzed C(sp3)-H bond functionalization was written by Machida, Mizuki;Mori, Keiji. And the article was included in Chemistry Letters in 2018.Related Products of 61150-57-0 This article mentions the following:

A highly diastereoselective synthesis of tetralin-fused spirooxindole derivatives was described. Treatment of benzylidene oxindoles with a catalytic amount of Sc(OTf)3 in refluxing hexane afforded the target compounds in good chem. yields with excellent diastereoselectivities (up to >20:1). Detailed investigation of the reaction mechanism revealed that both interconversion of the two diastereomers and their solubility difference in reaction medium were the key to achieving excellent diastereoselectivities. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Indirect synthesis of bromo-substituted aromatic compounds was written by Kakinami, Takaaki;Yoneda, Takehiko;Yonemaru, Satoshi;Okamoto, Tsuyoshi;Kajigaeshi, Shoji. And the article was included in Ube Kogyo Koto Senmon Gakko Kenkyu Hokoku in 1991.Application In Synthesis of 2-Bromo-4-methyl-6-nitroaniline This article mentions the following:

The reaction of bromobenzenamine derivatives with NaNO₂/H₂SO₄ in water and 30% phosphinic acid at 0-5° gave the bromo-substituted deamination products in fairly good yields. Bromination of benzeneamine gave 95% 2,4,6-tribromobenzenamine and deamination of the latter gave 97% 1,3,5-tribromobenzene. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Application In Synthesis of 2-Bromo-4-methyl-6-nitroaniline).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Application In Synthesis of 2-Bromo-4-methyl-6-nitroaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of (S)-2,6-dimethylphenylalanine via Ni(II) chelate induction was written by Zhang, Liang;Hou, Wenjie;Li, Ziyuan;Bai, Longxiang;Li, Tingyou. And the article was included in Xibei Yaoxue Zazhi in 2014.Name: 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

The paper is to synthesize the unnatural amino acid (S)-2,6-dimethylphenylalanine. 2,6-Dimethylbenzoic acid was reduced to produce 2,6-dimethylbenzyl alc., then the 2,6-dimethylbenzyl alc. was brominated to generate 2,6-dimethylbenzyl bromide. The 2,6-dimethylbenzyl bromide was then coupled with (S)-BPB-Ni-Gly complex to give (S)-Dmp-BPB-Ni complex, which was then decomposed by acid to obtain (S)-2,6-dimethylphenylalanine. (S)-2,6-Dimethylphenylalanine was synthesized with a total yield of 33.6%. This method has characteristics of cheap starting materials and simple exptl. procedure. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Name: 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Name: 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quantitative and Site-Directed Chemical Modification of Hypocrellins toward Direct Drug Delivery and Effective Photodynamic Activity was written by Deng, Hong;Liu, Xin;Xie, Jie;Yin, Rong;Huang, Naiyan;Gu, Ying;Zhao, Jingquan. And the article was included in Journal of Medicinal Chemistry in 2012.Quality Control of N-(5-Bromopentyl)phthalimide This article mentions the following:

For photodynamic therapy (PDT) treatment of microvascular diseases, drugs are delivered via blood circulation and the targets are vasculature endothelial cells, for which the contradictory requirements of hydrophilicity and lipophilicity of the drugs have been achieved by liposome preparations Herein, it is demonstrated that the drug delivery and target affinity are achieved by a single chem. compound, hypocrellin B (I)(HB) selected from three novel aminoalkanesulfonic acid HB derivatives I exhibits a much higher PDT activity (IC₅₀ = 22 nM) on human gastric carcinoma BGC823 cells than HB, while it has no cellular toxicity in the dark. On the basis of estimation of the clin. required concentration according to relative PDT activity and clin. criteria, it can be predicted that I is directly deliverable to and PDT effective on target cells. The enhanced red absorption and superhigh photoactivity suggest that 6 is more powerful for PDT of tumors than HB. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Quality Control of N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Quality Control of N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rapid Synthesis of Alkoxyamine Hydrochloride Derivatives from Alkyl Bromide and N,N’-Di-tert-butoxycarbonylhydroxylamine [(Boc)₂NOH] was written by Jayasekara, P. Suresh;Jacobson, Kenneth A.. And the article was included in Synthetic Communications in 2014.HPLC of Formula: 57293-19-3 This article mentions the following:

The conventional route to alkoxyamine hydrochloride derivatives is by reaction of alkyl bromides with N-hydroxyphthalimide or N-hydroxysuccinimide followed by addition of hydrazine and HCl. Transformation of an alkyl bromide to the corresponding alkoxyamine hydrochloride can be accomplished more rapidly in good yields without using hazardous hydrazine by reaction of (Boc)₂NOH (N,N’-di-tert-butoxycarbonylhydroxylamine) and alkyl bromide followed by addition of HCl. Alkoxyamine hydrochlorides are powerful reagents in organic synthesis that can be used to synthesize alkoxyimino derivatives after condensation with a ketone or aldehyde. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Anti-Alzheimer’s multitarget-directed ligands with serotonin 5-HT₆ antagonist, butyrylcholinesterase inhibitory, and antioxidant activity was written by Marcinkowska, Monika;Bucki, Adam;Panek, Dawid;Siwek, Agata;Fajkis, Nikola;Bednarski, Marek;Zygmunt, Malgorzata;Godyn, Justyna;Del Rio Valdivieso, Alvaro;Kotanska, Magdalena;Kolaczkowski, Marcin;Wieckowska, Anna. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2019.Category: bromides-buliding-blocks This article mentions the following:

Serotonin 5-HT₆ receptors, butyrylcholinesterase (BuChE) and oxidative stress are related to the pathophysiol. of Alzheimer’s disease. Inhibition of BuChE provides symptomatic treatment of the disease and the same effect was demonstrated for 5-HT₆ antagonists in clin. trials. Oxidative stress is regarded as a major and primary factor contributing to the development of Alzheimer’s disease; therefore, antioxidant agents may provide a disease-modifying effect. Combining BuChE inhibition, 5-HT₆ antagonism, and antioxidant properties may result in multitarget-directed ligands providing cognition-enhancing properties with neuroprotective activity. On the basis of the screening of the library of 5-HT₆ antagonists against BuChE, we selected two compounds and designed their structural modifications that could lead to improved BuChE inhibitory activity. We synthesized two series of compounds and tested their affinity and functional activity at 5-HT₆ receptors, BuChE inhibitory activity and antioxidant properties. Compound 12(I) with K_i and K_b values against 5-HT₆ receptors of 41.8 and 74 nM, resp., an IC₅₀ value of 5 μM against BuChE and antioxidant properties exceeding the activity of ascorbic acid is a promising lead structure for further development of anti-Alzheimer’s agents. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Category: bromides-buliding-blocks).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary