Synthesis of Polysubstituted 2-Naphthols by Palladium-Catalyzed Intramolecular Arylation/Aromatization Cascade was written by Cai, Jinhui;Wang, Zhen-Kai;Zhang, Yun-Hao;Yao, Fei;Hu, Xu-Dong;Liu, Wen-Bo. And the article was included in Advanced Synthesis & Catalysis in 2020.Reference of 61150-57-0 This article mentions the following:
A palladium-catalyzed intramol. α-arylation and defluorinative aromatization strategy for the synthesis of polysubstituted 2-naphthols, e.g., 1-(3-hydroxynaphthalen-2-yl)ethan-1-one, is reported. With ortho-bromobenzyl-substituted α-fluoroketones RCH2C(F)(C(O)R2)C(O)R1 (R = 2-bromophenyl, 2-bromopyridin-3-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc., R1 = Me, Et, Ph, R2 = Et, OMe, OEt, Ot-Bu) as the substrates and palladium acetate/triphenylphosphine as the catalyst system, this method features good functional group tolerance, readily available catalyst and starting materials, and high yields. The applications of the strategy are demonstrated by the synthesis of useful building blocks, such as naphtha[2,3-b]furan, naphthol AS-D, and ligands/catalysts. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Reference of 61150-57-0).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 61150-57-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary