Discovery of novel 1-arylmethylpyrrolidin-2-ylethanolamines as calcium-sensing receptor antagonists was written by Gavai, Ashvinikumar V.;Vaz, Roy J.;Mikkilineni, Amarendra B.;Roberge, Jacques Y.;Liu, Yalei;Lawrence, R. Michael;Corte, James R.;Yang, Wu;Bednarz, Mark;Dickson, John K.;Ma, Zhengping;Seethala, Ramakrishna;Feyen, Jean H. M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Product Details of 6515-58-8 This article mentions the following:
A 3D quant. structure-activity relationship study for inhibition of the calcium-sensing receptor in the aryloxypropanolamine series predicted that these mols. adopt a U-shaped conformation with pi-stacking between the two aromatic rings. This hypothesis led to the discovery of novel 1-arylmethylpyrrolidin-2-ylethanolamines capable of antagonizing the calcium-sensing receptor with potency comparable to that of NPS-2143. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Product Details of 6515-58-8).
3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 6515-58-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary