Synthesis of 3-phenylethynylphenol. (A novel high-temperature phenyl acetylene endcapper for arylene ethers) was written by Jayaraman, S.;Srinivasan, R.;McGrath, J. E.. And the article was included in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) in 1993.Safety of 3-Bromophenyl acetate This article mentions the following:
PhCCH was condensed with m-XC6H4OAc (X = Br, I) to give 3-(phenylethynyl)phenyl acetate, which was methanolyzed to provide 3-(phenylethynyl)phenol, an endcapping agent for aromatic polyethers. 3-Ethynylphenol was similarly obtained. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Safety of 3-Bromophenyl acetate).
3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of 3-Bromophenyl acetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary