Synthesis of cytotoxic novel 9,11-secosterol analogs: Structure/activity studies was written by Kongkathip, Boonsong;Hasakunpaisarn, Anuch;Boonananwong, Suthinee;Kongkathip, Ngampong. And the article was included in Steroids in 2010.Product Details of 28322-40-9 This article mentions the following:
In an effort to determine the pharmaceutical utility and the structural requirements for activity against tumor cell lines, 30 novel 9,11-secosterol analogs with different side chains and degrees of oxidation at C-9, e.g. I, were synthesized starting from hecogenin. Evaluation of the synthesized compounds for cytotoxicity against KB, HeLa and MCF-7 cell lines revealed that some important structural features are required for activity. The presence of a cholesterol-type side chain, which appears to play a major role in determining the biol. activity, the existence of a ketone functional at C-9 is also crucial for anticancer activity whereas hydroxyl/ketone function at C-22 on the side chain did not increase cytotoxicity. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Product Details of 28322-40-9).
Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Product Details of 28322-40-9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary