Application of the Hammett relation to tetrasubsituted thiophenes. Kinetics of piperidino-debromination of 5-substituted 2-bromo-3-nitrothiophenes and 2-bromo-4-methyl-3-nitrothiophenes in methanol was written by Spinelli, D.;Consiglio, G.;Corrao, A.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1972.SDS of cas: 38239-45-1 This article mentions the following:
The kinetics of piperidino-debromination of six 5-substituted 2-bromo-3-nitrothiophenes and six 2-bromo-4-methyl-3-nitrothiophenes in MeOH were determined The results were correlated with σp- values (ρ = 3.21 for the trisubstituted and 3.24 for the tetrasubstituted thiophenes). In the experiment, the researchers used many compounds, for example, 5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1SDS of cas: 38239-45-1).
5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 38239-45-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary