Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy was written by Wang, Fei;Chen, Ying;Rao, Weidong;Ackermann, Lutz;Wang, Shun-Yi. And the article was included in Nature Communications in 2022.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:
Disulfides are widely found in natural products and find a wide range of applications in life sciences, materials chem. and other fields. The preparation of disulfides mainly rely on oxidative couplings of two sulfur containing compounds This strategy has many side reactions and other shortcomings. Herein, authors describe the reductive nickel-catalyzed cross-electrophile coupling of unactivated alkyl bromides with sym. alkyl- and aryltetrasulfides to form alkyl-alkyl and aryl-alkyl unsym. disulfides. This approach for disulfide synthesis is practical, relies on easily available, unfunctionalized substrates, and is scalable. Author investigated the mechanism of this transformation and found that the tetrasulfide compound does not selectively break the central S-S bond, but regio-selectively generates trisulfide intermediates. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary