Chiral Ammonium Salt Catalyzed Asymmetric Alkylation of Unactivated Amides was written by Xu, Changming;Yang, Xinshuang. And the article was included in Synlett in 2022.Product Details of 83902-02-7 This article mentions the following:
A chiral spirocyclic quaternary ammonium salt catalyzed asym. alkylation of unactivated amides under homogeneous conditions has been developed, giving the target products with up to 60% ee. This novel methodol. provides a general and concise protocol for asym. α-functionalization of unactivated amides. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Product Details of 83902-02-7).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbonbromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Product Details of 83902-02-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary