Enantioselective Vinylogous Mannich-Type Reactions to Construct CF3S-Containing Stereocenters Catalysed by Chiral Quaternary Phosphonium Salts was written by Xu, Lijun;Yu, Longhui;Liu, Jun;Wang, Hongyu;Zheng, Changwu;Zhao, Gang. And the article was included in Advanced Synthesis & Catalysis in 2020.Name: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene This article mentions the following:
A series of benzyl trifluoromethyl sulfides bearing a nitro group was utilized as CF3S-containing building blocks R-2-O2NC6H3CH2SCF2X (R = H, 4-F, 5-Cl, 4-Br; X = F, CF3) to construct chiral CF3S-containing mols. I (R1 = naphthalen-1-yl, thiophen-2-yl, 4-methylphenyl, etc.) via enantioselective vinylogous Mannich-type reactions. In such reactions, high yields and enantioselectivities were obtained using chiral quaternary phosphonium salts II (R2 = Ph, 3-nitrophenyl) derived from amino acids. Moreover, a chiral cyclic urea bearing the CF3S moiety III was obtained from further transformation of the product I (R = H; R1 = Ph; X = F). In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Name: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene).
1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Name: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary