Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors was written by Ye, Xiaocong M.;Konradi, Andrei W.;Sun, Minghua;Yuan, Shendong;Aubele, Danielle L.;Dappen, Michael;Dressen, Darren;Garofalo, Albert W.;Jagodzinski, Jacek J.;Latimer, Lee;Probst, Gary D.;Sham, Hing L.;Wone, David;Xu, Ying-zi;Ness, Daniel;Brigham, Elizabeth;Kwong, Grace T.;Willtis, Chris;Tonn, George;Goldbach, Erich;Quinn, Kevin P.;Zhang, Hongbin H.;Sauer, John-Michael;Bova, Michael;Basi, Guriqbal S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Computed Properties of C8H4BrF3O This article mentions the following:
Structure-activity relation (SAR) of a novel, potent and metabolically stable series of benzo [3.2.1] bicyclic sulfonamide-pyrazoles as γ-secretase inhibitors are described. Compounds that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via oral dose, as well as those with high selectivity over Notch, are highlighted. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Computed Properties of C8H4BrF3O).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C8H4BrF3O
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary