2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 22426-14-8
Rhenium(I) complexation-dissociation strategy for synthesising fluorine-18 labelled pyridine bidentate radiotracers was written by Klenner, Mitchell A.;Zhang, Bo;Ciancaleoni, Gianluca;Howard, James K.;Maynard-Casely, Helen E.;Clegg, Jack K.;Massi, Massimiliano;Fraser, Benjamin H.;Pascali, Giancarlo. And the article was included in RSC Advances in 2020.Reference of 22426-14-8 This article mentions the following:
A novel fluorine-18 method employing rhenium(I) mediation is described herein. The method was found to afford moderate to high radiochem. yields of labeled rhenium(I) complexes. Subsequent thermal dissociation of the complexes enabled the radiosynthesis of fluorine-18 labeled pyridine bidentate structures which could not be radiofluorinated hitherto. This rhenium(I) complexation-dissociation strategy was further applied to the radiosynthesis of [18F]CABS13, an Alzheimer′s disease imaging agent, alongside other 2,2′-bipyridine, 1,10-phenanthroline and 8-hydroxyquinoline labeled radiotracers. Computational modeling of the reaction mechanism suggests that the efficiency of rhenium(I) activation may be attributed to both an electron withdrawal effect by the metal center and the formation of an acyl fluoride intermediate which anchors the fluoride subsequent to nucleophilic addition In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Reference of 22426-14-8).
2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 22426-14-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary