Asymmetric synthesis of functionalized tetrahydrofluorenones via an NHC-catalyzed homoenolate Michael addition was written by Shu, Tao;Li, Sun;Chen, Xiang-Yu;Liu, Qiang;von Essen, Carolina;Rissanen, Kari;Enders, Dieter. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Computed Properties of C8H4BrF3O This article mentions the following:
The first example of an N-heterocyclic carbene-catalyzed asym. desymmetrization of enal-tethered cyclohexadienones via an intramol. homoenolate Michael addition/esterification reaction was described. This new protocol offered a direct entry to various functionalized tetrahydrofluorenones with three contiguous stereocenters in high yields, good diastereoselectivities and excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Computed Properties of C8H4BrF3O).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C8H4BrF3O
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary