Molecular organization in the 6-bromo-6-deoxycyclodextrins, formation of molecular layers, and the first crystal structure of a selectivity perfunctionalized 灏?cyclodextrin was written by Nicolis, Ioannis;Coleman, Anthony W.;Charpin, Pierrette;Villain, Francoise;Zhang, Ping;Ling, Chang Chung;de Rango, Colette. And the article was included in Journal of the American Chemical Society in 1993.Synthetic Route of C42H63Br7O28 This article mentions the following:
6-Bromo-6-deoxycyclodextrins form stable monomol. at the air-H2O interface, with mol. areas of 180, 220 and 260 鑴?sup>2 for 浼?, 灏? and 绾?Br-CD. In the case of the heptakis-bromo-灏?CD compound 3 dimensional crystal structure was determined The heptakis-Br-灏?CD compound is monoclinic, space group P21, with a 15.714(3), b 15.917(6), c 30.102(4) 鑴? 灏?90.55(2)鎺? Z = 2. The structure is as a novel packing of dimeric 灏?cyclodextrin systems in a square arrangement. The layers are held together by Br-Br Van der Waals interactions giving rise to a quasi-continuous hydrophobic interface between the layers. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Synthetic Route of C42H63Br7O28).
Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C42H63Br7O28
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary