Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs was written by Becker, Lisa F.;Schwarz, Dennis H.;Wenz, Gerhard. And the article was included in Beilstein Journal of Organic Chemistry in 2014.Electric Literature of C42H63Br7O28 This article mentions the following:
Me and Et thioether groups were introduced at all primary positions of 浼?, 灏?, and 绾?cyclodextrin by nucleophilic displacement reactions starting from the corresponding per-(6-deoxy-6-bromo)cyclodextrins. Further modification of all 2-OH positions by etherification with iodo terminated triethylene glycol monomethyl ether (and tetraethylene glycol monomethyl ether, resp.) furnished water-soluble hosts. Especially the 灏?cyclodextrin derivatives exhibit very high binding potentials towards the anesthetic drugs sevoflurane and halothane. Since the resulting inclusion compounds are highly soluble in water at temperatures 閳?7 鎺矯 they are good candidates for new aqueous dosage forms which would avoid inhalation anesthesia. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Electric Literature of C42H63Br7O28).
Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Electric Literature of C42H63Br7O28
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary