N-Phthalimidoalkyl derivatives of 2灏?carbomethoxy-3灏?(4′-iodophenyl)tropane (灏?CIT): brain monoamine transporter affinity was written by Tamagnan, Gilles;Neumeyer, John L.;Gao, Yigong;Wang, Shaoyin;Kula Nora;Baldessarini, Ross J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1997.Recommanded Product: N-(5-Bromopentyl)phthalimide This article mentions the following:
A series of novel N-phthalimidoalkyl analogs I (n = 2-5, 8) for the stable phenyltropane 灏?CIT were synthesized and evaluated by selective radioligand binding assays for affinity to transporters for dopamine (DA), serotonin (5-HT) and norepinephrine (NE) in corpus striatum tissue from rat forebrain. 灏?CIT and I (n = 4, 5, 8) showed similarly greater affinity at 5-HT than DA transporters; this affinity was lost with I (n = 2, 3). These results are consistent with interference at a critical binding site for the tropane nitrogen on the transporter proteins and indicate that the tropane nitrogen atom can be substituted with large substituted alkyl moieties without loss of affinity or selectivity for amine transporters. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Recommanded Product: N-(5-Bromopentyl)phthalimide).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: N-(5-Bromopentyl)phthalimide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary