Month: February 2023

Design, Synthesis, and Structure-Activity Relationship of a Novel Series of GluN2C-Selective Potentiators was written by Zimmerman, Sommer S.;Khatri, Alpa;Garnier-Amblard, Ethel C.;Mullasseril, Praseeda;Kurtkaya, Natalie L.;Gyoneva, Stefka;Hansen, Kasper B.;Traynelis, Stephen F.;Liotta, Dennis C.. And the article was included in Journal of Medicinal Chemistry in 2014.Synthetic Route of C8H6BrFO2 This article mentions the following:

NMDA receptors are tetrameric complexes composed of GluN1 and GluN2A-D subunits that mediate a slow Ca²⁺-permeable component of excitatory synaptic transmission. NMDA receptors have been implicated in a wide range of neurol. diseases and thus represent an important therapeutic target. We herein describe a novel series of pyrrolidinones, e.g., I, that selectively potentiate only NMDA receptors that contain the GluN2C subunit. The most active analogs tested were over 100-fold selective for recombinant GluN2C-containing receptors over GluN2A/B/D-containing NMDA receptors as well as AMPA and kainate receptors. This series represents the first class of allosteric potentiators that are selective for diheteromeric GluN2C-containing NMDA receptors. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Synthetic Route of C8H6BrFO2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of potent, non-carbonyl inhibitors of fatty acid amide hydrolase (FAAH) was written by Gowlugari, Sumithra;DeFalco, Jeff;Nguyen, Margaret T.;Kaub, Carl;Chi, Candace;Duncton, Matthew A. J.;Emerling, Daniel E.;Kelly, Michael G.;Kincaid, John;Vincent, Fabien. And the article was included in MedChemComm in 2012.Electric Literature of C9H11BrO This article mentions the following:

Fatty acid amide hydrolase (FAAH) inhibition is a promising target for the treatment of pain, anxiety and depression. The vast majority of FAAH inhibitors contain an electrophilic moiety and are known to react covalently with the enzyme. Herein we present the discovery of potent inhibitors, such as RN-450 29, which are based upon a novel tetrahydropyridopyridine scaffold lacking an obvious electrophilic site, and which appear to inhibit FAAH in a reversible and non-covalent manner. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Electric Literature of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Trifluoromethylation of Alkyl Bromides was written by Kornfilt, David J. P.;MacMillan, David W. C.. And the article was included in Journal of the American Chemical Society in 2019.Name: 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

Copper oxidative addition into organohalides is a challenging two-electron process. In contrast, formal oxidative addition of copper to C_sp² carbon-bromine bonds can be accomplished by employing latent silyl radicals under photoredox conditions. This novel paradigm for copper oxidative addition has now been applied to a Cu-catalyzed cross-coupling of C_sp³-bromides. Specifically, a copper/photoredox dual catalytic system for the coupling of alkyl bromides with trifluoromethyl groups is presented. This operationally simple and robust protocol successfully converts a variety of alkyl, allyl, benzyl, and heterobenzyl bromides into the corresponding alkyl trifluoromethanes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Name: 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Name: 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A General Catalyst for Site-Selective C(sp³)-H Bond Amination of Activated Secondary over Tertiary Alkyl C(sp³)-H Bonds was written by Scamp, Ryan J.;Jirak, James G.;Dolan, Nicholas S.;Guzei, Ilia A.;Schomaker, Jennifer M.. And the article was included in Organic Letters in 2016.Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

The discovery of transition metal complexes capable of promoting general, catalyst-controlled and selective carbon-hydrogen (C-H) bond amination of activated secondary C-H bonds over tertiary alkyl C(sp³)-H bonds is challenging, as substrate control often dominates when reactive nitrene intermediates are involved. In this letter, we report the design of a new silver complex, [(Py₅Me₂)AgOTf]₂, that displays general and good-to-excellent selectivity for nitrene insertion into propargylic, benzylic, and allylic C-H bonds over tertiary alkyl C(sp³)-H bonds. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P₁(→P₃)-P₁ sites was written by Plummer, Mark;Hamby, James M.;Hingorani, Gary;Batley, Brian L.;Rapundalo, Stephen T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1993.COA of Formula: C23H26BrP This article mentions the following:

Cleardihydroxyethylene isostere-modified dipeptides I (R = Ph, Δ form; R = Ph, 1-naphthyl, cyclohexane form) and II (R¹ = Cl, H, R² = isobutyl; R¹ = H,. R² = Ph) incorporating topog. modified P₁(→P₃) side chains were prepared and investigated as structurally novel renin inhibitors. The binding affinities of peptides containing the above dihydroxyethylene isosteres exhibited near nanomolar affinities. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9COA of Formula: C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of novel 1-arylmethylpyrrolidin-2-ylethanolamines as calcium-sensing receptor antagonists was written by Gavai, Ashvinikumar V.;Vaz, Roy J.;Mikkilineni, Amarendra B.;Roberge, Jacques Y.;Liu, Yalei;Lawrence, R. Michael;Corte, James R.;Yang, Wu;Bednarz, Mark;Dickson, John K.;Ma, Zhengping;Seethala, Ramakrishna;Feyen, Jean H. M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Product Details of 6515-58-8 This article mentions the following:

A 3D quant. structure-activity relationship study for inhibition of the calcium-sensing receptor in the aryloxypropanolamine series predicted that these mols. adopt a U-shaped conformation with pi-stacking between the two aromatic rings. This hypothesis led to the discovery of novel 1-arylmethylpyrrolidin-2-ylethanolamines capable of antagonizing the calcium-sensing receptor with potency comparable to that of NPS-2143. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Product Details of 6515-58-8).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 6515-58-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Towards rigid-rod polyelectrolytes via well-defined precursor poly(p-phenylene)s substituted by 6-iodohexyl side chains was written by Rau, I. U.;Rehahn, M.. And the article was included in Acta Polymerica in 1994.Quality Control of 1-Bromo-6-methoxyhexane This article mentions the following:

A synthetic strategy is presented to prepare readily soluble poly-p-phenylene (PP) electrolytes of well-defined mol. constitution and conveniently determinable d.p. PP having 6-phenoxyhexyl pendant groups is treated with Me₃SiI to give 6-iodohexyl pendant groups; condensation with EtO₂C-p-C₆H₄ONa followed by hydrolysis gives the desired rigid-rod polyelectrolytes. Under appropriate reaction conditions all steps occur highly selectively and almost quant.; no degradation of the polymer backbone occurs as verified by high resolution NMR spectroscopy and osmometric investigations. Thus, structurally homogeneous carboxy-containing PP of well-known d.p. are prepared In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Quality Control of 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Quality Control of 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photochemical Nickel-Catalyzed Reductive Migratory Cross-Coupling of Alkyl Bromides with Aryl Bromides was written by Peng, Long;Li, Zheqi;Yin, Guoyin. And the article was included in Organic Letters in 2018.Synthetic Route of C10H13BrO This article mentions the following:

A method to access 1,1-diarylalkanes from readily available, nonactivated alkyl bromides and aryl bromides via visible-light-driven nickel and iridium dual catalysis, wherein diisopropylamine (iPr₂NH) is used as the terminal stoichiometric reductant, is reported. Both primary and secondary alkyl bromides can be successfully transformed into the migratory benzylic arylation products with good selectivity. Addnl., this method showcases tolerance toward a wide array of functional groups and the presence of bases. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Synthetic Route of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Diastereo- and enantioselective conjugate addition of α-ketoesters to nitroalkenes catalyzed by a chiral Ni(OAc)2 complex under mild conditions was written by Nakamura, Ayako;Lectard, Sylvain;Hashizume, Daisuke;Hamashima, Yoshitaka;Sodeoka, Mikiko. And the article was included in Journal of the American Chemical Society in 2010.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

A highly efficient, catalytic, diastereo- and enantioselective conjugate addition of α-ketoesters to nitroalkenes has been devised. The reaction was applicable to various substrates. Notably, the combination of endogenous and exogenous bases was effective, allowing a small amount of the catalyst (0.1-1 mol % Ni) to promote the reaction efficiently. The synthetic utility of this reaction was demonstrated in the synthesis of substituted pyrrolidine derivatives, whose stereochem. is closely related to biol. important natural products such as kainic acid. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary