Month: February 2023

Selective Electron Transfer Reduction of Urea-Type Carbonyls was written by Huang, Huan-Ming;Procter, David J.. And the article was included in European Journal of Organic Chemistry in 2019.Reference of 14425-64-0 This article mentions the following:

Urea-type carbonyls in barbiturates undergo a highly chemoselective electron transfer reduction upon treatment with SmI₂/H₂O/LiBr. The process involves the formation, and further reduction, of unusual ketyl-type radical anions under mild conditions. Cyclic aminal products are obtained in good to excellent yield without recourse to pre-activation of the substrate or the use of metal hydride reagents. Furthermore, varying the protic additive used in conjunction with SmI₂ allows intermediate hemiaminals to be obtained. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Reference of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Room-Temperature Synthesis of 1,3,5-Tri(het)aryl Benzene from Nitroalkenes Using Pd(OAc)₂: Complete Mechanistic and Theoretical Studies was written by Midya, Siba P.;Mondal, Subal;Islam, Abu S. M.;Rashid, Ambreen;Mondal, Sahidul;Paul, Ankan;Ghosh, Pradyut. And the article was included in Organic Letters in 2022.Recommanded Product: 96761-85-2 This article mentions the following:

Herein, a room-temperature catalytic pathway for 1,3,5-tri(het)aryl benzene derivatives I [R = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.] via Pd(OAc)₂-catalyzed cascade cyclotrimerization of nitroalkenes was presented. This newly developed C-C bond-forming methodol. takes place in a cascade manner with the initial pallado-Morita-Baylis-Hillman (MBH) type adduct. The broad substrate scopes, functional group tolerance, and different aryl-substituted benzene derivatives made this methodol. more attractive. Furthermore, the mechanistic understanding through isolation of intermediates and DFT studies of the catalytic cycle provide requisite insight into the methodol. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2Recommanded Product: 96761-85-2).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 96761-85-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly stereoselective synthesis of aryl/heteroaryl-C-nucleosides via the merger of photoredox and nickel catalysis was written by Ma, Yingying;Liu, Shihui;Xi, Yifan;Li, Hongrui;Yang, Kai;Cheng, Zhihao;Wang, Wei;Zhang, Yongqiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Recommanded Product: 179232-29-2 This article mentions the following:

A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Recommanded Product: 179232-29-2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 179232-29-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of coumarin linked fluoroquinolones, phthalimides and naphthalimides as potential DNA gyrase inhibitors was written by Kamal, A.;Satyanarayana, M.;Devaiah, V.;Rohini, V.;Yadav, J. S.;Mullick, B.;Nagaraja, V.. And the article was included in Letters in Drug Design & Discovery in 2006.Category: bromides-buliding-blocks This article mentions the following:

A hybrid mol. synthesis strategy is employed to develop new mols. with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Category: bromides-buliding-blocks).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and anti-proliferative activity evaluation of N3-acyl-N5-aryl-3,5-diaminoindazole analogues as anti-head and neck cancer agent was written by Lee, Jinho;Kim, Jina;Hong, Victor Sukbong;Park, Jong-Wook. And the article was included in Daru, Journal of Pharmaceutical Sciences in 2014.Product Details of 1130165-74-0 This article mentions the following:

Head and neck squamous cell carcinoma (HNSCC) is the 11th leading cancer by incidence worldwide. Surgery and radiotherapy were the major treatment for patients with HNSCC while chemotherapy become an important treatment option for locally advanced HNSCC. Understanding of the mol. mechanisms underlying HNSCC impelled the development of targeted therapeutic agents. The development and combinations of targeted therapies in different cellular pathways may be needed to fulfill the unmet needs of current HNSCC chemotherapy. A series of N3-acyl-N5-aryl-3,5-diaminoindazoles were synthesized and their antiproliferative activities were evaluated against human cancer cell lines, Caki, A549, AMC-HN1, AMC-HN3, AMC-HN4, AMC-HN6, and SNU449. The cellular selectivity of compound was obtained by the modification of substituent at N5-aryl group of 3,5-diaminoindazole. The compounds 2-(4-ethoxyphenyl)-N-{5-[2-fluoro-4-(morpholine-4-carbonyl)phenylamino]-1H-indazol-3-yl}acetamide and 2-(4-ethoxyphenyl)-N-{5-[2-fluoro-4-(4-methylpiperazine-1-carbonyl)phenylamino]-1H-indazol-3-yl}acetamide showed more than 7-fold selectivity for AMC-HN4 and AMC-HN3, resp. 3-Acylamino-N-arylaminoindazole analogs were used as hits in the development of anticancer drug for HNSCC. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromo-3-fluorobenzoate (cas: 1130165-74-0Product Details of 1130165-74-0).

Ethyl 4-bromo-3-fluorobenzoate (cas: 1130165-74-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 1130165-74-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Aromatic components analysis of fresh and rotten Penacus orientalis by HS-SPME and GC-MS was written by Xue, Yu-ping;Lan, Xin. And the article was included in Shipin Gongye (Shanghai, China) in 2014.Application of 56523-59-2 This article mentions the following:

The aromatic components of fresh and rotten Penacus orientalis were extracted by HS-SPME and identified by GC-MS. Then 100 μm PDMS microextraction fibers were used for sample pretreatment, with result that fresh prawn meat had 34 kinds of flavor composition, while rotten prawn meat had 48 kinds and quantified them. The result of the flavor characteristics and sensory evaluation were consistent. The results showed that the HS-SPME-GC-MS was suitable for anal. of prawn meat flavor composition method, which could be used in the anal. of volatile compounds as a quality indicator, with sensory evaluation for products quality evaluation, products classification, etc. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Application of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chiral Chalcogenide-Catalyzed Enantioselective Electrophilic Hydrothiolation of Alkenes was written by Liang, Yaoyu;Jiao, Hui;Zhang, Hang;Wang, You-Qing;Zhao, Xiaodan. And the article was included in Organic Letters in 2022.Related Products of 128-08-5 This article mentions the following:

A new strategy for the construction of chiral sulfides by catalytic enantioselective hydrothiolation of alkenes via an electrophilic pathway has been developed. Using this strategy, cyclic and acyclic unactivated alkenes efficiently afforded various chiral products in the presence of electrophilic sulfur reagents and silanes through chiral chalcogenide catalysis. The obtained products were easily transformed into other types of valuable chiral sulfur-containing compounds Mechanistic studies revealed that the superior construction of chiral thiiranium ion intermediate is the key to achieving such a transformation. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Related Products of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of the Hammett relation to tetrasubsituted thiophenes. Kinetics of piperidino-debromination of 5-substituted 2-bromo-3-nitrothiophenes and 2-bromo-4-methyl-3-nitrothiophenes in methanol was written by Spinelli, D.;Consiglio, G.;Corrao, A.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1972.SDS of cas: 38239-45-1 This article mentions the following:

The kinetics of piperidino-debromination of six 5-substituted 2-bromo-3-nitrothiophenes and six 2-bromo-4-methyl-3-nitrothiophenes in MeOH were determined The results were correlated with σp- values (ρ = 3.21 for the trisubstituted and 3.24 for the tetrasubstituted thiophenes). In the experiment, the researchers used many compounds, for example, 5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1SDS of cas: 38239-45-1).

5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 38239-45-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. design, synthesis, and enzymatic BACE-1 and cell assays was written by Garino, Cedrik;Tomita, Taisuke;Pietrancosta, Nicolas;Laras, Younes;Rosas, Roselyne;Herbette, Gaetan;Maigret, Bernard;Quelever, Gilles;Iwatsubo, Takeshi;Kraus, Jean-Louis. And the article was included in Journal of Medicinal Chemistry in 2006.Computed Properties of C13H14BrNO2 This article mentions the following:

Twenty novel β-secretase inhibitors containing biarylpiperazine moieties belonging to naphthyl and coumarinyl series were designed for their potential use in Alzheimer’s disease therapy. Enzymic and cell-based assays have been carried out. The biol. results clearly demonstrate that specific substituents located at the N₄-position of the piperazine ring result in excellent in vitro inhibitory potency (IC₅₀ values ranging between 40 and 70 nM). Variable temperature NMR and modeling studies are consistent with the obtained biol. data, since these studies confirmed that introduction at the N₄-position of the piperazine ring allows productive interactions within the BACE-1 active site, which appear to be determinative for high BACE-1 inhibitory activity. These results are of particular interest since some of the new analogs belonging to the naphthyl series are almost one log more active than the best inhibitor of the similar family recently reported. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

De Novo Synthesis of Phenols and Naphthols through Oxidative Cycloaromatization of Dienynes was written by Rong, Ming-Guang;Qin, Tian-Zhu;Liu, Xin-Rui;Wang, Hong-Fa;Zi, Weiwei. And the article was included in Organic Letters in 2018.Related Products of 85118-24-7 This article mentions the following:

In this work, a rhodium-catalyzed oxidative cycloaromatization of dienynes, which provides a highly straightforward and efficient way to access polysubstituted naphthols and phenols under mild conditions, is described. Challenged electron-withdrawing groups are well tolerated in this protocol, and late-stage Ph ring formation is demonstrated. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Related Products of 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary