Month: February 2023

Synthesis and evaluation of aryl boronic acids as fluorescent artificial receptors for biological carbohydrates was written by Craig, Sandra. And the article was included in Bioorganic Chemistry in 2012.HPLC of Formula: 166821-88-1 This article mentions the following:

Carbohydrates in various forms play a vital role in numerous critical biol. processes. The detection of such saccharides can give insight into the progression of such diseases such as cancer. Boronic acids react with 1,2 and 1,3 diols of saccharides in non-aqueous or basic aqueous media. Herein, we describe the design, synthesis and evaluation of three bisboronic acid fluorescent probes, each having about ten linear steps in its synthesis. Among these compounds that were evaluated, 9b was shown to selectively label HepG2, liver carcinoma cell line within a concentration range of 0.5-10 μM in comparison to COS-7, a normal fibroblast cell line. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1HPLC of Formula: 166821-88-1).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 166821-88-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Substituent effects on the mass spectra of substituted phenyl acetates was written by Gamble, A. A.;Gilbert, J. R.;Tillett, J. G.. And the article was included in Organic Mass Spectrometry in 1971.Category: bromides-buliding-blocks This article mentions the following:

The mass spectra of a series of meta- and para-substituted phenyl acetates were examined Substituent effects were correlated with Δ(AP-IP) values (AP = appearance potential; IP = ionization potential) and by using the Harrison and Chin approach. The bond-cleavage and rearrangement reactions of Ph acetates are compared with the corresponding reactions of acetanilides and the differences attributed to the degree of transmission of polar effects in the 2 systems. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Category: bromides-buliding-blocks).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly selective electroreductive linear dimerization of electron-deficient vinylarenes was written by Ning, Shulin;Zheng, Lianyou;Bai, Ya;Wang, Shutao;Wang, Siyu;Shi, Lingling;Gao, Qiansong;Che, Xin;Zhang, Zhuoqi;Xiang, Jinbao. And the article was included in Tetrahedron in 2021.HPLC of Formula: 474709-71-2 This article mentions the following:

A direct electroreductive dimerization of electron-deficient vinylarenes R¹R²C:CR³R⁴ (R¹ = Ph, 4-NCC₆H₄, pyridin-4-yl, etc., R² = R³ = R⁴ = H; R¹ = 4-EtO₂CC₆H₄, R² = Me, Ph, R³ = R⁴ = H; R¹ = 4-MeO₂CC₆H₄, R² = H, R³ = Me, R⁴ = H, Me; etc.) for the synthesis of 1,4-diarylbutanes R¹R²CH-CR³R⁴-CR³R⁴-CHR¹R² as been developed using a simple undivided cell with inexpensive carbon electrodes at room temperature The control and deuterium-labeling experiments of electroreductive dimerization suggest that the hydrogen source comes from the solvent CH₃CN. This protocol provides a mild and efficient route for the construction of C-C bond in moderate to good yields with high regioselectivity and broad substrate scope. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2HPLC of Formula: 474709-71-2).

Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 474709-71-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of N-sulfenylimines from disulfides and primary methanamines was written by Kawecki, Robert. And the article was included in Journal of Organic Chemistry in 2022.Reference of 128-08-5 This article mentions the following:

N-sulfenylimines (sulfenimines, thiooximes, N-alkylidenesulfenamides) were efficiently synthesized through the reaction of primary amines and disulfides with NBS or bromine. This reaction can be carried out in an open flask at room temperature without the need for any transition metal-containing additives. The use of thiols instead of disulfides gave similar results. A wide range of amines were reacted with aryl and alkyldisulfides, resulting in the formation of sulfenimines in a yield of 44-99%. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Reference of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Reference of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Total Synthesis of Glycinocins A-C was written by Corcilius, Leo;Elias, Nabiha T.;Ochoa, Jessica L.;Linington, Roger G.;Payne, Richard J.. And the article was included in Journal of Organic Chemistry in 2017.Application of 28322-40-9 This article mentions the following:

The glycinocins are a class of calcium-dependent, acidic cyclolipopeptide antibiotics structurally related to the clin. approved daptomycin. Herein, we describe a divergent total synthesis of glycinocins A-C, which differ in the structure of a branched α,β-unsaturated fatty acyl moiety. The three natural products exhibited calcium-dependent antimicrobial activity against Staphylococcus aureus and Bacillus subtilis with MICs ranging from 5.5 to 17 μM. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Application of 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

From hexa-peri-hexabenzocoronene to “superacenes” was written by Iyer, Vivekanantan S.;Wehmeier, Mike;Brand, J. Diedrich;Keegstra, Menno A.;Mullen, Klaus. And the article was included in Angewandte Chemie, International Edition in English in 1997.Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl This article mentions the following:

The polyphenylene I was prepared and characterized. Intramol. cyclodehydration of I with AlCl₃ and copper triflate in CS₂ afforded a black solid, which gave a broad mass spectral peak in the mass range expected for the analogous C₂₂₂ graphite unit. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Macrocyclic 2,2′-Bibenzimidazole Ruthenium(II) Chromophore as a Versatile Building Block for Supramolecular Devices was written by Sorsche, Dieter;Rau, Sven. And the article was included in European Journal of Inorganic Chemistry in 2014.Computed Properties of C7H7BrN2O2 This article mentions the following:

The authors present the synthesis of a macrocyclic Ru(II) complex I(PF₆)₂ that combines the versatile photophysics and supramol. chem. of biimidazole Ru(II) chromophores with a macrocyclic geometry that allows for its introduction into mech. interlocked frameworks. Structural information on the core framework was gained from a solid-state structure. The new supramol. building block shows that the principal photophysics of the Ru chromophore, i.e., the cation-driven light-switch effect, are retained during the formation of the macrocycle. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Computed Properties of C7H7BrN2O2).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C7H7BrN2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and study of the antioxidant activity of symmetrical and unsymmetrical sulfides based on 3-[4-hydroxy(methoxy)aryl]-1-bromopropanes was written by Prosenko, A. E.;Terakh, E. I.;Gorokh, E. A.;Khomchenko, A. S.;Panferov, M. A.. And the article was included in Neftekhimiya in 2003.Category: bromides-buliding-blocks This article mentions the following:

Synthesis of structural analogs of bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl]sulfide (stabilizer SO-3) – sym. and unsym. sulfides with different number of tert-Bu ortho-substituents in the structure of phenol fragments. A comparative study of the antioxidant activity of the synthesized compounds in model reactions of the autoxidation of lard and vaseline oil was carried out. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Many-membered heterocyclic compounds. XII. Formation of 15-pentadecanolide from 15-bromopentadecanoic acid was written by Stoll, M.. And the article was included in Helvetica Chimica Acta in 1947.Product Details of 56523-59-2 This article mentions the following:

Because the method of Kerschbaum (C.A. 21, 2118) for the lactonization of higher ω-Br fatty acids, using their Ag salts, gives very low yields, this reaction is studied in detail, using other salts and various solvents and concentrations The results are given in a table. The best results are obtained when the K 15-bromopentadecanoate is lactonized in a specially designed apparatus in MeCOEt, giving 85% 15-pentadecanolide (I), b_0.1 122°, m. 32-6°. Using the method of Hunsdiecker, et al. (French 839,188), with and without K₂CO₃, yields of 82.8% I are obtained in both cases. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Product Details of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors was written by Soliman, Beatrice;Wang, Ning;Zagotto, Giuseppe;Pockes, Steffen. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2019.Related Products of 954-81-4 This article mentions the following:

Imidazolylbutyl cyanoguanidines, such as N-cyano-N’-4-(4-imidazolyl)butyl-N”-2-(phenylthio)ethylguanidine, previously identified as highly potent agonists at the human histamine H₄ receptor (hH₄R), display certain drawbacks in pharmacokinetics, which led to the attempt to replace the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and N-methylpiperazine) as potential bioisosteres. Besides these changes, a variation of the spacer length (C₃-C₅) connecting the heterocycle and the cyanoguanidine moiety was made to possibly trigger the selectivity towards the resp. HRs. Investigations in radioligand-binding assays of the synthesized compounds I [X = CH₂, O, S, NMe; Y = CH₂, S; Z = (CH₂)_n; n = 1-3] exhibited only very weak activity at the hH₁R and hH₃R, while nearly all compounds were inactive at the hH₂R and hH₄R. In the case of piperidine-containing compounds, moderate affinities at the hH₃R over the single-digit micromolar range were detected. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary