Month: February 2023

Synthesis of 4-fluoro-3-phenoxytoluene was written by Zhao, Wen-xian;Wang, De-kun;Zhou, Yan-li. And the article was included in Jingxi Huagong in 2004.Application of 452-62-0 This article mentions the following:

4-Fluoro-3-phenoxytoluene (I) was synthesized by Ullmann coupling reaction of 3-bromo-4-fluorotoluene (II) and phenol. When the molar ratio of PhONa to II was 3:1 with 15% (mol) of CuO as catalyst and DMA as solvent, the reaction ran at 160 閳?165 鎺矯 for 5 h to give I in 88% yield. The structure of I was confirmed by elementary anal., ¹HNMR, IR, and MS. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Application of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One-Pot Copper-Catalyzed Three-Component Reaction of Sulfonyl Azides, Alkynes and Allylamines To Access 2,3-Dihydro-1H-imidazo[1,2-a]indoles was written by Jin, Hongwei;Liu, Daohong;Zhou, Bingwei;Liu, Yunkui. And the article was included in Synthesis in 2020.Reference of 85118-24-7 This article mentions the following:

A copper-catalyzed multicomponent reaction of sulfonyl azides, alkynes and allylamines affording 2,3-dihydro-1H-imidazo-[1,2-a]indoles in moderate yields was reported. Four C-N bonds were constructed by way of azide-alkyne cycloaddition (CuAAC) and double Ullmann-type coupling reactions in a one-pot process. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Reference of 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cobalt-Catalyzed C(sp²)-C(sp³) Suzuki-Miyaura Cross Coupling was written by Ludwig, Jacob R.;Simmons, Eric M.;Wisniewski, Steven R.;Chirik, Paul J.. And the article was included in Organic Letters in 2021.Quality Control of Isopentyltriphenylphosphonium bromide This article mentions the following:

A cobalt-catalyzed method for the C(sp²)-C(sp³) Suzuki-Miyaura cross coupling of aryl boronic esters and alkyl bromides is described. Cobalt-ligand combinations were assayed with high-throughput experimentation, and cobalt(II) sources with trans-N,N’-dimethylcyclohexane-1,2-diamine (DMCyDA, L¹) produced optimal yield and selectivity. The scope of this transformation encompassed steric and electronic diversity on the aryl boronate nucleophile as well as various levels of branching and synthetically valuable functionality on the electrophile. Radical trap experiments support the formation of electrophile-derived radicals during catalysis. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Quality Control of Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Quality Control of Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

New fluorescent indolium and quinolinium dyes for applications in aqueous halide sensing was written by Geddes, Chris D.;Douglas, Peter;Moore, Christopher P.;Wear, Trevor J.;Egerton, Peter L.. And the article was included in Dyes and Pigments in 1999.Electric Literature of C15H29BrO2 This article mentions the following:

Bromide and teraphenylborate salts of six new highly fluorescent dyes, produced by the reaction of two heterocyclic nitrogen bases (6-methoxyquinoline and harman) with 8-bromooctanoic acid, 11-bromoundecanoic acid, and 15-bromopentadecanoic acid have been prepared Unlike the bases themselves, the quaternary salts are water soluble and have fluorescence characteristics independent of pH in the range 7-11. Both the fluorescence intensity and fluorescence lifetime of these dyes are reduced in the presence of aqueous halide ions, allowing halide concentrations to be determined accurately at concentrations of importance to both medicine and industry. All the dyes have been characterized in terms of steady state fluorescence spectra and steady-state Stern-Volmer anal. The Stern-Volmer constants for the dyes are compared to those obtained for some com. available dyes. The prospects for using these dyes in halide sensor devices are discussed. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Electric Literature of C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity was written by Bearrood, Thomas E.;Aguirre-Figueroa, Guadalupe;Chan, Jefferson. And the article was included in Bioconjugate Chemistry in 2020.SDS of cas: 107317-58-8 This article mentions the following:

High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. To facilitate the detection, mol. imaging, and sorting of stem cells, a green fluorescent probe based on the xanthene dye scaffold was recently developed. However, green dyes are less amenable to multicolor imaging because most com. reagents are also green. Overcoming this limitation will enable the simultaneous tracking of multiple stem cell markers. Herein, we report the development of a red congener, red-AlDeSense. Through chem. tuning we were able to achieve excellent isoform selectivity and chemostability, a good turn on response, and enhanced cellular uptake and reactivity. Importantly, red-AlDeSense represents one of only a few turn-on sensors in the red region that use the d-PeT quenching mechanism. By employing red-AlDeSense and a green anti-CD44 antibody, we were able to demonstrate staining of these two stem cell markers is independent of one another in A549 lung adenocarcinoma cells. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8SDS of cas: 107317-58-8).

Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.SDS of cas: 107317-58-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

C-H Bond Functionalization via Hydride Transfer: Formation of 浼?Arylated Piperidines and 1,2,3,4-Tetrahydroisoquinolines via Stereoselective Intramolecular Amination of Benzylic C-H Bonds was written by Vadola, Paul A.;Carrera, Ignacio;Sames, Dalibor. And the article was included in Journal of Organic Chemistry in 2012.Safety of Methyl 2-bromo-4-fluorobenzoate This article mentions the following:

We here report a study of the intramol. amination of sp³ C-H bonds via the hydride transfer cyclization of N-tosylimines (HT-amination). In this transformation, 5-aryl aldehydes are subjected to N-toluenesulfonamide in the presence of BF₃璺疧Et₂ to effect imine formation and HT-cyclization, leading to 2-arylpiperidines and 3-aryl-1,2,3,4-tetrahydroisoquinolines in a one-pot procedure. We examined the reactivity of a range of aldehyde substrates as a function of their conformational flexibility. Substrates of higher conformational rigidity were more reactive, giving higher yields of the desired products. However, a single substituent on the alkyl chain linking the N-tosylimine and the benzylic sp³ C-H bonds was sufficient for HT-cyclization to occur. In addition, an examination of various arenes revealed that the electronic character of the hydridic C-H bonds dramatically affects the efficiency of the reaction. We also found that this transformation is highly stereoselective; 2-substituted aldehydes yield cis-2,5-disubstituted piperidines, while 3-substituted aldehydes afford trans-2,4-disubstituted piperidines. The stereoselectivity is a consequence of thermodn. control. The pseudoallylic strain between the arene and tosyl group on the piperidine ring is proposed to rationalize the greater stability of the isomer with the aryl ring in the axial position. This preferential placement of the arene is proposed to affect the observed stereoselectivity. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Safety of Methyl 2-bromo-4-fluorobenzoate).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of Methyl 2-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives was written by Chawla, Gita;Kumar, Umesh;Bawa, Sandhya;Kumar, Jagdish. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2012.Safety of Methyl 3-bromo-4-fluorobenzoate This article mentions the following:

Several 2,5-disubstituted-1,3,4-oxadiazoles and 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized and characterized by elemental analyses and spectral data. These compounds were screened for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. Compound I showed excellent anti-inflammatory and remarkable analgesic activity with reduced ulcerogenic and lipid peroxidation activity when compared with ibuprofen. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Safety of Methyl 3-bromo-4-fluorobenzoate).

Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Methyl 3-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stable and easily available sulfide surrogates allow a stereoselective activation of alcohols was written by Merad, Jeremy;Matyasovsky, Jan;Stopka, Tobias;Brutiu, Bogdan R.;Pinto, Alexandre;Drescher, Martina;Maulide, Nuno. And the article was included in Chemical Science in 2021.Product Details of 14425-64-0 This article mentions the following:

Isothiouronium salts N(CH₃)₂C(=N⁺(CH₃)₂)SR.X^– (R = prop-2-en-1-yl, 2-(4-methoxyphenyl)ethyl, 3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propyl, etc.; X = Br, I, SbF₆, BF₄, PF₆) are easily accessible and stable compounds Herein, their use as versatile deoxasulfenylating agents enabling a stereoselective, thiol-free protocol for synthesis of thioethers RSR¹ (R¹ = prop-2-yn-1-yl, 1-phenylethyl, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl, etc.) from alcs. R¹OH was reported. The method is simple and scalable and tolerates a broad range of functional groups otherwise incompatible with other methods. Late-stage modification of several pharmaceuticals provides access to multiple analogs of biol. relevant mols. Performed experiments give insight into the reaction mechanism. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Product Details of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Strategy for the Synthesis of Sulfonamides on DNA was written by Liu, Wei;Deng, Wei;Sun, Saisai;Yu, Chunyan;Su, Xubo;Wu, Aliang;Yuan, Youlang;Ma, Zhonglin;Li, Ke;Yang, Hongfang;Peng, Xuanjia;Dietrich, Justin. And the article was included in Organic Letters in 2019.Category: bromides-buliding-blocks This article mentions the following:

An efficient method is reported to synthesize sulfonamides on DNA from sulfinic acids or sodium sulfinates and amines in the presence of iodine under mild conditions. This method demonstrates a major expansion of scope of sulfonamide formation on DNA through the utilization of a novel sodium carbonate-sodium sulfinate bifunctional reagent class. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Category: bromides-buliding-blocks).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Allylboronates from Vinyl Triflates and 浼?Chloroboronates by Reductive Nickel Catalysis was written by Qiao, Jin-Bao;Zhao, Zhen-Zhen;Zhang, Ya-Qian;Yin, Kai;Tian, Zhi-Xiong;Shu, Xing-Zhong. And the article was included in Organic Letters in 2020.Related Products of 4457-67-4 This article mentions the following:

Allylboronates are unique building blocks widely used in organic synthesis, but the construction of cyclic allylboranates remains a challenging subject. The authors demonstrate here a mild and efficient access to this type of compound through the cross-electrophile coupling of vinyl triflates and 浼?chloroboronates. The reaction proceeded with a good substrate scope and good functional group compatibility. The ready availability of vinyl triflates from ketones, as well as the rich chem. of allylboranates, makes the authors’ method suitable for the divergent modification of biol. active compounds Preliminary mechanistic studies revealed that 浼?chloroboronates were activated via a radical process. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Related Products of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Related Products of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary