Month: February 2023

Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPAR绾?and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects was written by Tilekar, Kalpana;Hess, Jessica D.;Upadhyay, Neha;Bianco, Alessandra Lo;Schweipert, Markus;Laghezza, Antonio;Loiodice, Fulvio;Meyer-Almes, Franz-Josef;Aguilera, Renato J.;Lavecchia, Antonio;C S, Ramaa. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 615-55-4 This article mentions the following:

Monotargeting anticancer agents suffer from resistance and target nonspecificity concerns, which can be tackled with a multitargeting approach. The combined treatment with HDAC inhibitors and PPAR绾?agonists has displayed potential antitumor effects. Based on these observations, this work involves design and synthesis of mols. I (Ar = Ph, pyridin-2-yl, benzo[d]thiazol-2-yl, etc.) that can simultaneously target PPAR绾?and HDAC. Several out of 25 compounds inhibited HDAC4, and six compounds acted as dual-targeting agents. Compound I (Ar = 2-bromo-4,6-difluorophenyl) was the most potent, with activity toward PPAR绾?EC₅₀ = 0.245娓璏 and HDAC4 IC₅₀ = 1.1娓璏. Addnl., compounds I (Ar = 4-methylphenyl, 2-bromo-4,6-difluorophenyl) were cytotoxic to CCRF-CEM cells (CC₅₀ = 2.8 and 9.6娓璏, resp.), induced apoptosis, and caused DNA fragmentation. Furthermore, compound I (Ar = 4-methylphenyl) modulated the expression of c-Myc, cleaved caspase-3, and caused in vivo tumor regression in CCRF-CEM tumor xenografts. Thus, this study provides a basis for the rational design of dual/multitargeting agents that could be developed further as anticancer therapeutics. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Recommanded Product: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photochromic dihetarylethenes 3. Synthesis and photochromic properties of 1,2-bis[2-methyl-5-(benzoxazol-2-yl)thien-3-yl]hexafluorocyclopentene was written by Krayushkin, M. M.;Stoyanovich, F. M.;Zolotarskaya, O. Yu.;Martynkin, A. Yu.;Ivanov, V. L.;Uzhinov, B. M.. And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 1999.Application of 29421-99-6 This article mentions the following:

The title compound, i.e., 2,2′-[(3,3,4,4,5,5-hexafluoro-1-cyclopentene-1,2-diyl)di-(2-methyl-3,5-thiophenediyl)]bis[benzoxazole] was prepared and its photochromic properties were studied. The compound thus prepared did not exhibit fluorescent properties in either open or cyclic form. In the experiment, the researchers used many compounds, for example, 4-Bromo-5-methylthiophene-2-carboxylic acid (cas: 29421-99-6Application of 29421-99-6).

4-Bromo-5-methylthiophene-2-carboxylic acid (cas: 29421-99-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 29421-99-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Multifunctional electron-transporting indolizine derivatives for highly efficient blue fluorescence, orange phosphorescence host and two-color based white OLEDs was written by Wan, Jing;Zheng, Cai-Jun;Fung, Man-Keung;Liu, Xiao-Ke;Lee, Chun-Sing;Zhang, Xiao-Hong. And the article was included in Journal of Materials Chemistry in 2012.Safety of 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl This article mentions the following:

Derivatives of 1-azaindolizine are 1st used as electron-transporting host materials for hybrid fluorescence/phosphorescence white organic LEDs (F/P-WOLED). Of the azaindolizine derivatives, a blue fluorescent material BPPI (3-(4,4′-biphenyl)-2-diphenyl-1-azaindolizine) has: (1) blue emission with high quantum yields, (2) good morphol. and thermal stabilities, (3) electron-transporting properties, and (4) a sufficiently high triplet energy level to act as a host for red or yellow-orange phosphorescent dopants. The multifunctional BPPI enables adaptation of several simplified device configurations. For example, a nondoped blue fluorescent device exhibits good performance with an external quantum efficiency of 3.16% and Commission Internationale de l’Eclairage coordinates of (0.15, 0.07). A high-performance orange phosphorescent device has a high current efficiency of 23.9 cd A^-1. Using BPPI, a F/P-WOLED with a simplified structure, stable emissions and respectable performance (current and external quantum efficiencies of 17.8 cd A^-1 and 10.7%, resp.) was demonstrated. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2Safety of 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regio- and stereo-selective olefinic C-H functionalization of aryl alkenes in ethanol was written by Shen, Cong;Zhu, Yuhang;Jin, Shuqi;Xu, Kejie;Luo, Shuxin;Xu, Lixia;Zhong, Guofu;Zhong, Liangjun;Zhang, Jian. And the article was included in Organic Chemistry Frontiers in 2022.Synthetic Route of C8H6BrFO2 This article mentions the following:

N,N-bidentate-chelation-assisted 浼? and 灏?olefinic C-H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio- and stereo-selectivities was reported. The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclometallation and seven-membered endo-cyclometallation. The aerobic protocols feature wide functionality tolerance, high selectivities and yields, mild conditions and scalable preparation, and the directing group can be easily removed to afford Boc-protected amine by simple reduction In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Synthetic Route of C8H6BrFO2).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

2′- and 3′- cholesterol-conjugated adenosine and cytosine nucleoside building blocks: synthesis of lipidic nucleic acids was written by Manoharan, Muthiah;Inamati, Gopal;Tivel, Kathleen L.;Conklin, Boyd;Ross, Bruce S.;Cook, P. Dan. And the article was included in Nucleosides & Nucleotides in 1997.Name: N-(5-Bromopentyl)phthalimide This article mentions the following:

2′- And 3′- cholesterol-conjugated adenosine and cytosine nucleoside building blocks for lipidic nucleic acids were prepared Large scale synthesis and purification of two oligonucleotides were completed in 100 mg scale. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Name: N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Location effect of triptycene on the photovoltaic performance of carbazole-based dyes was written by Yan, Mao;Zhu, Yi-Zhou;Yan, Yi-Qiao;Wang, Qun-Hui;Yin, Guan-Lin;Zheng, Jian-Yu. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.SDS of cas: 128-08-5 This article mentions the following:

Due to the unique three-dimensional spatial structure and special electronic properties, triptycene has been applied in dye-sensitized solar cells. Herein, two dyes JY76/JY77 featuring triptycene at the different substitution position of carbazole donor have been synthesized, and location effect of triptycene on the photovoltaic performance of devices has been investigated. Lateral derived triptycene endows JY77 much more enhanced capability of impeding the interface charge recombination than JY76 which triptycene was decorated at terminal. Finally, JY77-sensitized solar cells exhibit around 20% higher power conversion efficiency (PCE) than that of JY76. The photovoltaic properties are further tuned by co-sensitization strategy, and better PCEs are obtained. Under AM 1.5G irradiation, cells fabricated by the synergic adsorption of JY77 and JY75, achieve the highest PCE of 8.01%. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5SDS of cas: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.SDS of cas: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Solid superacids catalyzed organic synthesis. 3. Nafion-H catalyzed condensation of acetophenone derivatives. A preparative route to 1,3,5-triarylbenzenes. was written by Yamato, Takehiko;Hideshima, Chieko;Tashiro, Masashi;Prakash, G. K. Surya;Olah, George A.. And the article was included in Catalysis Letters in 1990.Synthetic Route of C24H15Br3 This article mentions the following:

Nafion-H, a perfluorinated resin sulfonic acid, catalyzes condensation of acetophenones I (R = H, R¹ = H, alkyl, MeO, Br, Cl; R = Br, R¹ = H) to provide 1,3,5-triarylbenzenes under relatively mild conditions. Reactions are clean and water formed as byproduct does not deactivate the catalyst. However, ortho-substituted acetophenones and 2-acetylthiophene gave no condensation product. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2Synthetic Route of C24H15Br3).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Synthetic Route of C24H15Br3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Density functional theory study of the substituent effect on the structure, conformation and vibrational spectra in halosubstituted anilines was written by Haruna, Kabiru;Alenaizan, Asem A.;Al-Saadi, Abdulaziz A.. And the article was included in RSC Advances in 2016.COA of Formula: C6H5Br2N This article mentions the following:

A comparative d. functional theory (DFT) study exploring the structural and spectroscopic properties of the complete set of halosubstituted anilines with the halogens being F, Cl and Br was carried out. This study aims at understanding the effect of the type, number and positions of halogen substituents on the inversion barrier, geometrical properties and vibrational frequencies. The compounds were exclusively predicted to exist in the near-planar pyramidal form. While the order of stability is noted to be independent of the type of halogen substituents, the size of the inversion barrier is predicted to be sensitive to their number and positions, in accordance with former theor. and exptl. reports. The higher number of halogens leads to a more pronounced planarity character of the amino group. The deactivating nature of halogen atoms is believed to enhance the lone-pair electron delocalization in the order of bromo- > chloro- > fluoroanilines. An unusually strong electron delocalization nature is predicted to exist in the case of tetra- and penta-substituted haloanilines. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4COA of Formula: C6H5Br2N).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Modular solid-phase synthetic approach to optimize structural and electronic properties of oligo-boronic acid receptors and sensors for the aqueous recognition of oligosaccharides was written by Stones, Duane;Manku, Sukhdev;Lu, Xiaosong;Hall, Dennis G.. And the article was included in Chemistry – A European Journal in 2004.Synthetic Route of C12H16BBrO2 This article mentions the following:

This article describes the design and optimization of the first entirely modular, parallel solid-phase synthetic approach for the generation of well-defined polyamine oligo-boronic acid receptors and fluorescence sensors for complex oligosaccharides. The synthetic approach allows an effective building of the receptor polyamine backbone, followed by the controlled diversification of the amine benzylic side chains. This approach enabled the testing, in a modular fashion, of the effect of different aryl-boronic acid units substituted with un-encumbering para electron-withdrawing or electron-donating groups. The feasibility of this approach toward automated synthesis was also investigated with the assembly of a sub-library of receptors by means of the Irori MiniKan technol. Several sub-libraries of anthracene-capped sensors containing two or three aryl-boronic acids were synthesized, and their binding to a series of model disaccharides was examined in neutral aqueous media. The calculation of association constants by fluorescence titrations confirmed that subtle changes in the structures of the inter-amine spacers in the polyamine backbone can have a significant effect on the stability of the resulting complexes. Most importantly, this study led to the determination of the preferred electronic characteristics for the aryl-boronate units, and suggests that a new generation of receptors containing very electron-poor aryl-boronic acids could lead to a significant improvement of binding affinities. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1Synthetic Route of C12H16BBrO2).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Synthetic Route of C12H16BBrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

An efficient Pd(II)-(2-aminonicotinaldehyde) complex as complementary catalyst for the Suzuki-Miyaura coupling in water was written by Thunga, Sanjeeva;Poshala, Soumya;Anugu, Naveenkumar;Konakanchi, Ramaiah;Vanaparthi, Satheesh;Kokatla, Hari Prasad. And the article was included in Tetrahedron Letters in 2019.Computed Properties of C16H17Br This article mentions the following:

An efficient new Pd(II)-(2-aminonicotinaldehyde)-catalyzed Suzuki-Miyaura coupling of the aryl halides RX (R = Ph, thiophen-2-yl, 4-(imidazo[1,2-a]pyridin-2-yl)phenyl, etc.; X = Br, Cl, I) and organoboronic acids ArB(OH)₂ (Ar = Ph, 3,5-dimethylphenyl, naphthalen-1-yl, etc.) at moderate temperature in water is described. Low catalyst loading, easy accessibility, being an air-stable catalyst, functional group compatibility, and water as the reaction medium are some of the key features of this synthetic method. This protocol is also applicable for gram scale. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Computed Properties of C16H17Br).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C16H17Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary