Month: February 2023

Chemistry of heavy carbene analogs R₂M, M = Si, Ge, Sn. IX. Properties and thermolysis of new 7-silabicyclo[2.2.1]heptadienes was written by Appler, Hubertus;Gross, Lutz W.;Mayer, Bernd;Neumann, Wilhelm P.. And the article was included in Journal of Organometallic Chemistry in 1985.Product Details of 452-62-0 This article mentions the following:

Factors governing the ease and mechanism of 7-silabicyclo[2.2.1]heptadienes thermolysis in order to generate free silylenes and the corresponding benzene derivatives are investigated. For this purpose, 29 new compounds, I–IV (R¹ = Cl, Me, p-tolyl; R² = Cl, Me, Ph, p-tolyl, R³, R⁴ = H, Me, Ph; R⁵ = H, CO₂Me; R⁶, R⁷, R⁸, R⁹ = H, Me; R⁶ = R⁹ = H; R⁷R⁸ = benzo), have been prepared No indications for a polar mechanism or an intermediate biradical could be found. The degradation is 1st order in all cases investigated, and is enhanced by Ph groups at the bridgehead C atoms, if a conformation coplanar with the basic ring is allowed by the neighboring substituents, but is not enhanced by Ph groups at the Si. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Product Details of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Reductive Conjugate Addition of Primary Alkyl Bromides to Enones To Form Silyl Enol Ethers was written by Huihui, Kierra M. M.;Shrestha, Ruja;Weix, Daniel J.. And the article was included in Organic Letters in 2017.Safety of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Conjugate addition of organometallic reagents to enones to form silyl enol ether products is a versatile method to difunctionalize activated olefins, but the organometallic reagents required can be limiting. The reductive cross-electrophile coupling of unhindered primary alkyl bromides with enones and chlorosilanes to form silyl enol ether products is catalyzed by a nickel-complexed ortho-brominated terpyridine ligand. The conditions are compatible with a variety of cyclic/acyclic enones and functional groups. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Safety of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly sensitive and selective fluorescence chemosensors containing phenanthroline moieties for detection of Zn²⁺ and Cd²⁺ ions was written by Quan, Cong;Liu, Jiayu;Sun, Wei;Cheng, Xinjian. And the article was included in Chemical Papers in 2020.Related Products of 22426-14-8 This article mentions the following:

It is extremely necessary to detect heavy metals sensitively and selectively, especially the ions that will cause great harm to humans and the environment. This work deals with two fluorescent chemosensors and their outstanding role when detecting Zn²⁺ and Cd²⁺ ions. First, a small mol. chemosensor (TPB) has been designed and synthesized via Suzuki reaction using one part of benzene-1,3,5-triyltriboronic acid and three parts of 2-bromo-1, 10-phenanthroline as starting materials. And then, its corresponding macromol. fluorescent chemosensor (PTPB) was synthesized. The IR spectra, mass spectrometry (MS), and ¹H-NMR were used to study the structures of TPB and PTPB. From what has been studied, the TPB and PTPB were stable in a relative wide pH range. As soon as the Cd²⁺ and Zn²⁺ ions added, fluorescence of the two sensors TPB and PTPB was changed obviously. In addition, PTPB was found have better performance to both Cd²⁺ and Zn²⁺ than TPB through the ”mol. wire” mechanism. Job’s plots were also be tested, showing that the combination ratio of TPB and PTPB to Cd²⁺ and Zn²⁺ were both 3:1 (ion/sensor). In addition, the min. detection limits of the macromol. chemosensor PTPB for Cd²⁺ and Zn²⁺ reached 0.424娓璏 and 1.27娓璏, resp. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Related Products of 22426-14-8).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Related Products of 22426-14-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPAR浼?and PPAR绾?agonist activity was written by Fracchiolla, Giuseppe;Lavecchia, Antonio;Laghezza, Antonio;Piemontese, Luca;Trisolini, Raffaella;Carbonara, Giuseppe;Tortorella, Paolo;Novellino, Ettore;Loiodice, Fulvio. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Application In Synthesis of 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

PPARs are ligand-activated transcription factors that govern lipid and glucose homeostasis and play a central role in cardiovascular disease, obesity, and diabetes. Herein, we present screening results for a series of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives, some of which are potent PPAR绾?agonists as well as PPAR浼?agonists. To investigate the binding modes of the most interesting derivatives into the PPAR浼?and PPAR绾?binding clefts and evaluate their agonist activity, docking experiments, mol. dynamics simulations, and MM-PBSA anal. were performed. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Application In Synthesis of 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Application In Synthesis of 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Electrochemical Properties of Donor-Acceptor-Conjugated Polymers Based on Carbazole-EDOT Derivatives with Different Electron-Withdrawing Groups was written by Liu, Junlei;Hou, Weiwei;Xu, Ruoteng;Gao, Yijing;Xu, Lintie;Jiang, Linxiang;Zhang, Cheng. And the article was included in ACS Applied Polymer Materials in 2022.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

A series of donor (D)-acceptor (A)-conjugated monomers (ECzE-NB and ECzE-AQ) were designed and synthesized by EDOT-carbazole-EDOT (ECzE) acting as a donor (D) and anthraquinone (AQ) and nitrobenzene (NB) acting as acceptors (A) in this study. The corresponding polymer films (PECzE, PECzE-NB, and PECzE-AQ) were obtained by electrochem. polymerization, and then the effects of different acceptors on the structure and electrochem. performance of the polymers were studied. Through NMR, mass spectrometry (MS), and Fourier transform IR spectroscopy (FT-IR), it was proved that the monomers were successfully synthesized. The results of the electrochem. performance test illustrated that the electrochem. behavior of PECzE was a typical nondiffusion-controlled process. When the c.d. was 0.1 mA/cm², the specific capacity of PECzE was 8.41 mF/cm² with a rather good rate performance. However, the electrochem. behaviors of PECzE-NB and PECzE-AQ were different from that of PECzE owing to the ability of hole injection and spatial structures of the monomers changed by introducing electron-withdrawing groups. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application In Synthesis of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Alkylboronic Esters from Copper-Catalyzed Borylation of Primary and Secondary Alkyl Halides and Pseudohalides was written by Yang, Chu-Ting;Zhang, Zhen-Qi;Tajuddin, Hazmi;Wu, Chen-Cheng;Liang, Jun;Liu, Jing-Hui;Fu, Yao;Czyzewska, Maria;Steel, Patrick G.;Marder, Todd B.;Liu, Lei. And the article was included in Angewandte Chemie, International Edition in 2012.COA of Formula: C13H14BrNO2 This article mentions the following:

Authors have developed an unprecedented copper-catalyzed cross-coupling reaction of unactivated alkyl halides and pseudohalides with diboron reagents. This reaction can be used to prepare primary and secondary alkylboronic esters with diverse structures and functional groups, many of which would be difficult to access by other means. The reaction is efficient, practically simple, and gives easy isolation of the products which can be further enhanced through the use of polymer-supported ligands. It is also reported a mild and practical protocol for the Suzuki-Miyaura coupling of alkylboronic esters with both aryl bromides and chlorides. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4COA of Formula: C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.COA of Formula: C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photoinduced electron transfer quenching and sugar effects on the electrostatic interaction between an anionic Ru(II) complex and cationic bipyridinium derivatives functionalized with boronic acids was written by Uddin, Jamal Md.;DiCesare, Nicolas;Lakowicz, Joseph R.. And the article was included in Inorganica Chimica Acta in 2012.Formula: C12H16BBrO2 This article mentions the following:

The photoinduced electron transfer quenching of an anionic ruthenium(II) metal-ligand-complex (Ru(dpp(SO₃Na)))₂(mcbpy)Cl₂ by two boronic acid functionalized benzyl viologen (BV²⁺) derivatives has been investigated as well as their response to sugar. The electrostatic interaction between these two charge species lead to the formation of static quenching which is removed in presence of sugar due to the formation of a neutral zwitterionic quencher. Spectral data, quenching parameters and sugar titration curves are presented and discussed in term of future developments of optical sensors for sugar. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1Formula: C12H16BBrO2).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Formula: C12H16BBrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Core-Modified Third-Generation Light-Driven Molecular Motors was written by Berrocal, Jose Augusto;Pfeifer, Lukas;Heijnen, Dorus;Feringa, Ben L.. And the article was included in Journal of Organic Chemistry in 2020.Quality Control of Dimethyl 4,5-dibromophthalate This article mentions the following:

The synthesis and characterization of a series of light-driven third-generation mol. motors featuring various structural modifications at the central aromatic core are presented. We explore a number of substitution patterns, such as 1,2-dimethoxybenzene, naphthyl, 1,2-dichlorobenzene, 1,1′:2′,1”-terphenyl, 4,4”-dimethoxy-1,1′:2′,1”-terphenyl, and 1,2-dicarbomethoxybenzene, considered essential for designing future responsive systems. In many cases, the synthetic routes for both synthetic intermediates and motors reported here are modular, allowing for their post-functionalization. The structural modifications introduced in the core of the motors result in improved solubility and a bathochromic shift of the absorption maxima. These features, in combination with a structural design that presents remote functionalization of the stator with respect to the fluorene rotors, make these novel motors particularly promising as light-responsive actuators in covalent and supramol. materials. In the experiment, the researchers used many compounds, for example, Dimethyl 4,5-dibromophthalate (cas: 859299-66-4Quality Control of Dimethyl 4,5-dibromophthalate).

Dimethyl 4,5-dibromophthalate (cas: 859299-66-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Quality Control of Dimethyl 4,5-dibromophthalate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy was written by Meyers, Marvin J.;Arhancet, Graciela B.;Hockerman, Susan L.;Chen, Xiangyang;Long, Scott A.;Mahoney, Matthew W.;Rico, Joseph R.;Garland, Danny J.;Blinn, James. R.;Collins, Joe T.;Yang, Shengtian;Huang, Horng-Chih;McGee, Kevin F.;Wendling, Jay M.;Dietz, Jessica D.;Payne, Maria A.;Homer, Bruce L.;Heron, Marcia I.;Reitz, David B.;Hu, Xiao. And the article was included in Journal of Medicinal Chemistry in 2010.Synthetic Route of C9H6BrF3O3 This article mentions the following:

We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early analogs were poorly soluble and had a propensity to inhibit the hERG channel. Remarkably, both of these challenges were overcome by incorporation of a single carboxylate moiety. Structural modification of carboxylate-containing lead R-4g with a wide range of substituents at each position of the pyrazoline ring resulted in R-12o, which shows excellent activity against MR and reasonable pharmacokinetic profile. Introduction of conformational restriction led to a novel series characterized by exquisite potency and favorable steroid receptor selectivity and pharmacokinetic profile. Oral dosing of 3S,3aR-27d (PF-3882845) in the Dahl salt sensitive preclin. model of salt-induced hypertension and nephropathy showed blood pressure attenuation significantly greater than that with eplerenone, reduction in urinary albumin, and renal protection. As a result of these findings, 3S,3aR-27d was advanced to clin. studies. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-(trifluoromethoxy)benzoate (cas: 933785-18-3Synthetic Route of C9H6BrF3O3).

Methyl 4-bromo-2-(trifluoromethoxy)benzoate (cas: 933785-18-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C9H6BrF3O3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Mediated Deuterotrifluoromethylation of 浼?Diazo Esters was written by Hu, Mingyou;Xie, Qiqiang;Li, Xinjin;Ni, Chuanfa;Hu, Jinbo. And the article was included in Chinese Journal of Chemistry in 2016.Electric Literature of C10H11BrO2 This article mentions the following:

A copper-mediated deuterotrifluoromethylation of 浼?diazo esters RC(=N₂)CO₂CH₂CH₃ (R = C₆H₅, 4-BrC₆H₄CH₂, octanyl, naphth-1-yl, etc.) under the promotion of deuterium oxide (D₂O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds RC(CF₃)(D)(CO₂CH₂CH₃). This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some exptl. evidences to support the previously proposed trifluoromethylation mechanism. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Electric Literature of C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary